Health Effects of Occupational Exposures in PGDP Workers

Paducah气体扩散厂(PGDP)位于肯塔基州西部，约10英里以西 帕迪尤卡市。它目前雇佣了大约1700名工人；大约8000人在 该工厂自1952年开业以来一直在生产。该工厂位于农村地区，毗邻受保护地区 自然保育、野生动物和娱乐区。PGDP的主要功能一直是生产 浓缩铀，用于商业反应堆或作为其他工厂的原料，进一步浓缩铀 铀。工人、政府官员和周围社区对此表示担忧 工厂当前和过去的暴露对健康的潜在影响。这里提出的研究将 通过结合工作历史，完成持续的死亡率调查，以帮助解决这些问题 使用历史暴露数据为工厂的每个工人创建暴露度量， 该设施的历史。在具体目标1中，我们将对照其他现有名单验证工人名册 和原始文档。在具体目标2中，我们将制定一份全面的工作和工作历史清单 用于劳动力的纸质记录和电子文件。在具体目标3中，我们将创建工作曝光 整个工厂历史上化学和辐射暴露的矩阵。在具体目标4中，我们将 将工作历史记录数据与职务风险基准表链接，以估计单个员工的风险指标。在……里面 具体目标5，我们将评估工人死亡率与工作场所暴露的关系，使用 标准化死亡率和风险评估方法。在具体目标6中，我们将传达 向员工和管理层学习结果。 这些调查的首要目标是评估历史暴露对工人的影响 死亡率。PGDP是美国现存的唯一一座没有经历过 全面的职业健康研究。PGDP调查产生的数据将是 可与朴茨茅斯和橡树岭气体扩散厂之前的两项研究合并 设施。Paducah数据将大大增加合并数据库的统计能力，以 解决铀浓缩工人迫切的健康问题。

The Paducah Gaseous Diffusion Plant (PGDP) is located in Western Kentucky, about 10 miles west of the City of Paducah. It currently employs approximately 1700 workers; some 8,000 individuals have worked at the plant since it was opened in 1952. The plant is located in a rural area, adjacent to protected conservation, wildlife and recreation areas. The primary function of the PGDP has been to produce enriched uranium for use by commercial reactors or as feed material for other plants that further enrich the uranium. Workers, government officials and the surrounding community have raised concerns about potential health effects from current and past exposures at the plant. The studies proposed here will complete an ongoing mortality investigation to help address those concerns, by combining work histories with historical exposure data to create an exposure metric for each worker at the plant, throughout the history of the facility. In Specific Aim 1, we will validate the worker roster against other existing name lists and source documents. In Specific Aim 2, we will develop a comprehensive list of jobs and job histories for the workforce from paper records and electronic files. In Specific Aim 3, we will create a Job Exposure Matrix for chemical and radiation exposures throughout the history of the plant. In Specific Aim 4, we will link the Work History data with the Job Exposure Matrix to estimate individual worker exposure metrics. In Specific Aim 5, we will evaluate worker Mortality for relationships with workplace exposures using standardized mortality ratios and risk assessment approaches. In Specific Aim 6, we will communicate the study results to employees and management. The overarching goal of these investigations is to evaluate the impact of historical exposures on worker mortality. The PGDP is the only remaining gaseous diffusion plant in the US that has not undergone a comprehensive occupational health study. The data generated by the PGDP investigations will be available to merge with the two prior studies at the Portsmouth and Oak Ridge gaseous diffusion plant facilities. The Paducah data will add substantially to the statistical power of the combined database to address the pressing health concerns of uranium enrichment workers.