Exposure to Bisphenol A & Reproductive Effect in Humans

接触双酚 A

• 批准号: 7257804
• 负责人: De-Kun Li
• 金额: $ 62.45万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7257804
• 关键词: Exposure; Bisphenol; Reproductive; Effect; Humans

DESCRIPTION (provided by applicant): Bisphenol A (BPA) is strongly suspected as a human endocrine disrupter. We propose to follow up our earlier published preliminary report on the human reproductive toxicity of BPA among workers in four Chinese chemical plants. We expect to recruit (a) 300 current and former BPA-exposed workers (200 men and 100 women), (b) 300 spouses, for examining intermediate exposure levels, and (c) 300 offspring, for examining multigenerational effects. For each male worker, two controls with no history of exposure to BPA will be selected from local textile factories. Because of the smaller number of exposed female workers, four controls will be selected per exposed female worker, thus 800 controls with their spouses and offspring will be recruited. Our specific aims are as follows: (1) Among women (both exposed workers and spouses of male exposed workers), is there a relationship of exposure with sex hormone profile, menstrual disorders, frequency of sexual intercourse, time-to pregnancy, and spontaneous abortion? (2) Among men (both exposed workers and spouses of female exposed workers), is there a relationship of exposure with sex hormone profile, inhibin B levels, semen quality, and frequency of sexual intercourse? (3) Among the children of exposed workers, is there a relationship of parental exposure with sex ratio, birth weight, age at development of secondary sex features, menstrual characteristics, and sex hormone profile? Current BPA exposure will be obtained from air sampling through personal monitoring. Cumulative exposure will be estimated through a semi-quantitative job/exposure matrix. An in-person interview will be conducted to obtain detailed information on work history, reproductive and sexual history, and the age at puberty of offspring. Blood and semen samples will be evaluated for hormone levels and semen quality. The work will be conducted by the Shanghai Institute of Planned Parenthood Research and Fudan University (formerly Shanghai Medical University), Department of Occupational Health in collaboration with University of Washington. They have extensive experience in the data collection and lab analysis methods that will be used in the study. The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations.

描述（由申请人提供）：双酚A （BPA）被强烈怀疑是一种人体内分泌干扰物。我们建议跟进我们早先发表的关于双酚a对中国四家化工厂工人的人体生殖毒性的初步报告。我们希望招募(a) 300名目前和曾经接触过双酚a的工人（200名男性和100名女性），(b) 300名配偶，以检查中间暴露水平，(c) 300名后代，以检查多代影响。对于每名男性工人，将从当地纺织工厂中选择两名没有BPA接触史的对照者。由于受照女工人数较少，每名受照女工将选择4名对照，因此将招募800名对照及其配偶和子女。我们的具体目标如下：(1)在女性（暴露工人和男性暴露工人的配偶）中，暴露与性激素水平、月经紊乱、性交频率、怀孕时间和自然流产是否存在关系？(2)在男性（暴露工人和女性暴露工人的配偶）中，暴露与性激素水平、抑制素B水平、精液质量和性交频率是否存在关系？(3)暴露工人子女的父母暴露与性别比、出生体重、第二性征发育年龄、月经特征和性激素水平是否存在关系？目前的双酚a暴露量将通过个人监测从空气采样中获得。累积暴露将通过半定量的工作/暴露矩阵来估计。将进行面对面访谈，以获得有关工作经历、生育和性行为史以及子女青春期年龄的详细信息。血液和精液样本将被评估激素水平和精液质量。这项工作将由上海计划生育研究所和复旦大学（原上海医科大学）职业卫生学系与复旦大学合作进行