Molecular epidemiology of drug-resistant tuberculosis in Peru

秘鲁耐药结核病的分子流行病学

• 批准号: 7269265
• 负责人: MERCEDES C BECERRA
• 金额: $ 13.76万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-26 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7269265
• 关键词: Advisory Committees; Award; Biometry; Characteristics; Clinical; Collaborations; Data; Development; Drug Resistant Tuberculosis; Drug resistance in tuberculosis; Drug-sensitive; Epidemiologist; Epidemiology; Faculty; Funding; Grant; Household; Immunology; Individual; Link; Lung; Measures; Mentors; Molecular Epidemiology; Molecular Genetics; Morbidity - disease rate; Multi-Drug Resistance; Multidrug-Resistant Tuberculosis; Mutation; Mycobacterium tuberculosis; Natural History; Nested Case-Control Study; Patients; Peru; Public Health Schools; Research; Research Activity; Research Personnel; Research Training; Resistance; Social Medicine; Testing; Training; Tuberculosis; United States National Institutes of Health; career; cohort; cost; experience; fitness; medical schools; mortality; professor; programs

DESCRIPTION (provided by applicant): This revised application is for a Mentored Faculty Development Award to prepare Dr. Mercedes Becerra for a successful career as an independent investigator in tuberculosis epidemiology. Dr. Becerra completed a doctoral program in epidemiology at the Harvard School of Public Health and is currently Assistant Professor in the Department of Social Medicine of the Harvard Medical School. She now proposes a five-year training and research program that will consist of additional specialized training and an intensive research experience under the guidance of Dr. Eric J. Rubin as the Research Mentor; Dr. Howard Hiatt as the Career Development Mentor; and an Advisory Committee of experts in epidemiology, biostatistics, social medicine, immunology, and molecular genetics. The mentored project will be linked to ongoing research activities of the team of advisors. Tuberculosis is a leading cause of morbidity and mortality, and the emergence of multidrug-resistant (MDR) strains of M. tuberculosis threatens global tuberculosis control because these strains are much more difficult and expensive to treat than drug-sensitive strains. The candidate will test the hypothesis that mutations found in transmitted MDR M. tuberculosis are likely to be those associated with minimal fitness costs when compared to those found in MDR strains that are not transmitted. Specific aims are: (1) To measure the association between specific resistance-conferring mutations in M. tuberculosis and the occurrence of secondary cases in household contacts. (2) To assess the impact of other mutations in M. tuberculosis, and clinical and demographic characteristics, on these associations. The candidate will achieve these aims by conducting a case-control study nested in a clinical cohort of over 1,000 patients with pulmonary MDR tuberculosis in Peru, where she has developed productive collaborations. At the end of the grant period, the candidate will have gained substantial experience in the inclusion and analysis of molecular-genetic data in the methodologically rigorous study of the natural history and epidemiology of drug-resistant tuberculosis. The cumulative effect of this award will be to enable Dr. Becerra to compete successfully for NIH individual investigator funding and maximize her potential to pursue an academic career as a tuberculosis epidemiologist.

描述（由申请人提供）： 这个修订后的应用程序是一个指导教师发展奖准备博士梅赛德斯贝塞拉成功的职业生涯作为一个独立的调查员在结核病流行病学。贝塞拉博士在哈佛公共卫生学院完成了流行病学博士课程，目前是哈佛医学院社会医学系助理教授。她现在提出了一个为期五年的培训和研究计划，将包括额外的专业培训和密集的研究经验的指导下，博士埃里克J鲁宾作为研究导师;博士霍华德希亚特作为职业发展导师;和一个咨询委员会的专家在流行病学，生物统计学，社会医学，免疫学和分子遗传学。受指导的项目将与顾问小组正在进行的研究活动联系起来。结核病是发病率和死亡率的主要原因，并且多药耐药（MDR）结核分枝杆菌菌株的出现。结核病威胁着全球结核病控制，因为这些菌株比药物敏感菌株更难治疗，治疗费用也更高。候选人将检验在传播的MDR M中发现的突变的假设。结核病可能是那些与最小的健身成本相比，在MDR菌株中发现的那些不传播。具体目标是：（1）测量M中特定耐药突变之间的关联。结核病和家庭接触者中继发病例的发生。(2)评估M.结核病，临床和人口统计学特征，对这些协会。该候选人将通过在秘鲁的1,000多名肺MDR结核患者的临床队列中进行病例对照研究来实现这些目标，她在那里开展了富有成效的合作。在资助期结束时，候选人将在耐药结核病自然史和流行病学的严格方法研究中纳入和分析分子遗传数据方面获得大量经验。该奖项的累积效应将使Becerra博士能够成功竞争NIH个人研究者资助，并最大限度地发挥她作为结核病流行病学家的学术生涯的潜力。