Host and Microbial risk factors for drug-sensitive and resistant tuberculosis

药物敏感和耐药结核病的宿主和微生物危险因素

• 批准号: 8136605
• 负责人: MERCEDES C BECERRA
• 金额: $ 110.1万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8136605
• 关键词: Alcoholism; Archives; Basic Science; Behavior; Cessation of life; Clinical; Cohort Studies; Data; Databases; Decision Making; Development; Diabetes Mellitus; Disease; Disease Progression; Drug Resistant Tuberculosis; Drug resistance; Drug-sensitive; Environmental Risk Factor; Epidemic; Epidemiology; Exposure to; Extreme drug resistant tuberculosis; Family; Funding; Genetic Determinism; Genetic Polymorphism; Goals; Helminths; Household; Human; Individual; Infection; Intervention; Intestines; Lead; Lipids; Maps; Measures; Microbial Genetics; Minority; Modeling; Multi-Drug Resistance; Mutation; Mycobacterium tuberculosis; Organism; Patients; Peru; Phenotype; Population; Predisposition; Program Research Project Grants; Proteins; Public Health; Recruitment Activity; Resistance; Resistance profile; Risk; Risk Factors; Smoking; Therapeutic; Time; Tuberculin Test; Tuberculosis; United States National Institutes of Health; base; clinical research site; cohort; effective therapy; indexing; microbial; microbial host; micronutrient deficiency; novel; pathogen; transmission process; trend

PROVIDED. M. tuberculosis is a highly successful pathogen that infects over eight million people per year and leads to over 2 million deaths. One third of the world's population is believed to be infected with this organism, but only a small minority of those infected will go on to develop active disease. Although some risk factors for disease progression have been described, host and microbial mechanisms that lead to increased susceptibility are poorly understood. The identification of factors associated with the transmission and progression of drug sensitive and resistant tuberculosis may provide targets for focused clinical and public health interventions. Such interventions will be of particular importance for the control of drug resistant tuberculosis, since current control measures focus on the effective treatment of infectious cases. The long term goals are to elucidate factors involved in the emergence and transmission of multidrug (MDR) and extensively drug resistant (XDR) tuberculosis and to develop and implement interventions that target these factors in order to reduce tuberculosis progression and transmission. The specific aims of this project are to identify host, microbial and environmental risk factors for the development of drug sensitive (DS) and MDR tuberculosis and to archive strains characterized on the basis of their epidemiologic and clinical behavior so that they can be used in basic research on strain diversity and its contribution to MDR. We will also establish a comprehensive database which will allow real-time surveillance and be used for epidemic modeling and individual prediction models that will assist decision making regarding the treatment of drug resistant tuberculosis.

提供了 M.结核病是一种非常成功的病原体，每年感染800多万人， 超过两百万人死亡据信，世界上三分之一的人口感染了这种生物， 只有一小部分感染者会继续发展为活动性疾病。虽然一些风险因素， 已经描述了疾病进展，导致增加的宿主和微生物机制 易感性知之甚少。确定与传播有关的因素， 药物敏感和耐药结核病的进展可能为重点临床和公众提供目标， 卫生干预措施。这种干预措施对于控制耐药的 结核病是一个严重的问题，因为目前的控制措施侧重于有效治疗传染病病例。长 长期目标是阐明多药耐药（MDR）的发生和传播所涉及的因素， 广泛耐药（XDR）结核病，并制定和实施针对这些结核病的干预措施。 减少结核病的进展和传播。该项目的具体目标是 确定产生药物敏感（DS）和MDR的宿主、微生物和环境风险因素 结核病，并根据其流行病学和临床行为对菌株进行存档， 它们可用于菌株多样性及其对MDR贡献的基础研究。我们还将建立 一个全面的数据库，将允许实时监测，并用于流行病建模， 个体预测模型，这将有助于决策有关治疗耐药 结核