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Host and Microbial risk factors for drug-sensitive and resistant tuberculosis

药物敏感和耐药结核病的宿主和微生物危险因素

基本信息

批准号：
7936250
负责人：
MERCEDES C BECERRA
金额：
$ 101.01万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7936250
关键词：
Alcoholism Archives Basic Science Behavior Cessation of life Clinical Cohort Studies Data Databases Decision Making Development Diabetes Mellitus Disease Disease Progression Drug Resistant Tuberculosis Drug resistance Drug-sensitive Environmental Risk Factor Epidemic Epidemiology Exposure to Extreme drug resistant tuberculosis Family Funding Genetic Determinism Genetic Polymorphism Goals Helminths Household Human Individual Infection Intervention Intestines Lead Lipids Maps Measures Microbial Genetics Minority Modeling Multi-Drug Resistance Mutation Mycobacterium tuberculosis Organism Patients Peru Phenotype Population Predisposition Program Research Project Grants Proteins Public Health Recruitment Activity Resistance Resistance profile Risk Risk Factors Smoking Therapeutic Time Tuberculin Test Tuberculosis United States National Institutes of Health base clinical research site cohort effective therapy indexing microbial microbial host micronutrient deficiency novel pathogen transmission process trend

项目摘要

PROVIDED. M. tuberculosis is a highly successful pathogen that infects over eight million people per year and leads to over 2 million deaths. One third of the world's population is believed to be infected with this organism, but only a small minority of those infected will go on to develop active disease. Although some risk factors for disease progression have been described, host and microbial mechanisms that lead to increased susceptibility are poorly understood. The identification of factors associated with the transmission and progression of drug sensitive and resistant tuberculosis may provide targets for focused clinical and public health interventions. Such interventions will be of particular importance for the control of drug resistant tuberculosis, since current control measures focus on the effective treatment of infectious cases. The long term goals are to elucidate factors involved in the emergence and transmission of multidrug (MDR) and extensively drug resistant (XDR) tuberculosis and to develop and implement interventions that target these factors in order to reduce tuberculosis progression and transmission. The specific aims of this project are to identify host, microbial and environmental risk factors for the development of drug sensitive (DS) and MDR tuberculosis and to archive strains characterized on the basis of their epidemiologic and clinical behavior so that they can be used in basic research on strain diversity and its contribution to MDR. We will also establish a comprehensive database which will allow real-time surveillance and be used for epidemic modeling and individual prediction models that will assist decision making regarding the treatment of drug resistant tuberculosis.

提供。