Genetics of intersex: Antagonism between male and female pathways during gonadal development
Genetics of intersex: Antagonism between male and female pathways during gonadal development
双性遗传学：性腺发育过程中男性和女性途径之间的拮抗
批准号：
nhmrc : 611810
负责人：
Dr Pascal Bernard
金额：
$37.86万
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2010
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2010-01-01 至 2012-12-31
中文摘要
翻译
性发育障碍（DSD）是一种先天性疾病，其中染色体、性腺或解剖性别的发育是非典型的。据估计，1-100和1-300活产有DSD;然而，在80%的情况下，潜在的遗传缺陷是未知的。通常，性腺、睾丸或卵巢的命运由雄性（SRY）和雌性（Wnt-b-连环蛋白）基因的平衡作用决定。这些基因是如何相互对抗的？这种拮抗作用在DSD患者中是否失调？
英文摘要
Disorders of sex Development (DSD) are congenital conditions in which development of chromosomal, gonadal or anatomical sex is atypical. Estimates suggest that between 1-100 and 1-300 live birth have DSD; however, the underlying genetic defect is unknown in 80% of cases. Generally, the fate of the gonad, testis or ovary, is determined by the balanced action of male (SRY) and female (Wnt- b-catenin) genes. How do these genes oppose each other? Is this antagonism deregulated in DSD patients?
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