Novel and Traditional Risk Factors for Symptomatic PAD in Women

描述（由申请人提供）： 该项目将为候选人Aruna Pradhan博士作为心血管流行病学独立临床科学家的职业生涯做好准备，重点是外周动脉疾病（PAD）的风险评估，这是她感兴趣的科学领域。在奖励激活时，Pradhan博士将成为一名符合董事会资格的心脏病专家，并在波士顿布里格姆妇女医院（BWH）完成了她的奖学金培训。她的博士后研究活动一直在BWH预防医学部心血管疾病预防中心进行。该中心提供了一个科学的生产环境，以支持初级研究人员进行以人口为基础的流行病学研究。申请人提出了一项为期5年的研究计划，将前瞻性地评估女性PAD的新风险因素和传统风险因素，其中流行病学数据有限。要检查的风险因素可以分为三组之一：新的生物标志物，传统和行为的心血管风险因素，饮食影响。采用前瞻性队列设计，将在39，876名健康中年美国女性的女性健康研究中进行分析。该队列中的长期随访和高质量协变量数据提供了一个独特的机会，以前瞻性的方式研究大量特征良好的女性人群中PAD的潜在可改变的风险因素。在奖励期结束时，Pradhan博士将获得先进的流行病学技能和PAD研究方面的专业知识，这将使她能够独立进行预防和治疗这种疾病的研究。该提案旨在评估美国女性下肢动脉系统中广泛的新兴和传统危险因素与动脉粥样硬化发展之间的相关性。虽然先前有关男性这些风险因素的数据有限，但有关女性风险因素关系的信息极为稀少。感兴趣的特定暴露包括基于血液的生物标志物，传统的心血管风险因素，如糖尿病，肥胖和血压升高，行为风险因素，如吸烟和缺乏身体活动，以及饮食影响，如脂肪，抗氧化剂和碳水化合物摄入。(End摘要）

DESCRIPTION (provided by applicant): This project will prepare the candidate, Dr. Aruna Pradhan, for a career as an independent clinical scientist in cardiovascular epidemiology with a focus on risk assessment of peripheral arterial disease (PAD), her area of scientific interest. At the time of award activation, Dr. Pradhan will be a board eligible cardiologist having completed her fellowship training at the Brigham and Women's Hospital (BWH), Boston. Her post-doctoral research activities have been undertaken in the Center for Cardiovascular Disease Prevention within the Division of Preventive Medicine, BWH. The Center provides a scientifically productive environment for the support of junior investigators in the conduct of population-based epidemiologic research. The applicant proposes a 5-year program of research that will prospectively evaluate novel and traditional risk factors for PAD in women, among whom limited epidemiologic data exist. The risk factors to be examined may be categorized into one of three groups: novel biomarkers, traditional and behavioral cardiovascular risk factors, and dietary influences. Employing a prospective cohort design, analyses will be conducted in the Women's Health Study of 39,876 healthy middle-aged American women. The long-term follow-up and high quality covariate data in this cohort offer a unique opportunity to study, in a prospective manner, potentially modifiable risk factors for PAD in a large well-characterized population of women. At the conclusion of the award period, Dr. Pradhan will have acquired advanced epidemiologic skills and expertise in the study of PAD which will enable her to independently conduct research in prevention and treatment of this disease. This proposal seeks to evaluate the association between a broad range of emerging and traditional risk factors and the development of atherosclerosis in the lower extremity arterial system among American women. While prior limited data are available pertaining to these risk factors in men, information with regard to risk factor relationships in women are extremely sparse. Specific exposures of interest include blood based biomarkers, traditional cardiovascular risk factors such as diabetes, obesity, and elevated blood pressure, behavioral risk factors such as smoking and physical inactivity, and dietary influences such as fat, antioxidant, and carbohydrate intake. (End of Abstract)