Novel and Traditional Risk Factors for Symptomatic PAD in Women

女性症状性 PAD 的新的和传统的危险因素

• 批准号: 7210720
• 负责人: Aruna Das Pradhan
• 金额: $ 13.55万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-20 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7210720
• 关键词: Alcohol consumption; Alteplase; American; Antigens; Antioxidants; Apolipoproteins; Apolipoproteins B; Area; Aspirin; Atherosclerosis; Award; Behavioral; Biological Markers; Blood; Blood Banks; Blood Pressure; Blood specimen; Body fat; Boston; C-reactive protein; Carbohydrates; Cardiovascular Diseases; Cardiovascular system; Carotenoids; Clinical; Controlled Clinical Trials; Creatinine; Cross-Sectional Studies; Data; Data Collection; Development; Diabetes Mellitus; Diet Modification; Dietary Fiber; Disease; Dose; Enrollment; Environment; Epidemiologic Studies; Epidemiology; Evaluation; Fatty acid glycerol esters; Fellowship; Fibrin fragment D; Fibrinogen; Folate; Foundations; Funding; Glycosylated hemoglobin A; Grant; Group Processes; Health Professional; High Density Lipoprotein Cholesterol; Homocysteine; Homocystine; Hospitals; Incidence; Inflammation; Intake; Intercellular adhesion molecule 1; Intermittent Claudication; Intervention; Knowledge; Life Style; Lipoprotein (a); Lipoprotein (a-); Low-Density Lipoproteins; Lower Extremity; Malignant Neoplasms; Measurement; Obesity; Operative Surgical Procedures; Participant; Patient Self-Report; Peripheral; Peripheral arterial disease; Physical activity; Placebo Control; Plasma; Population; Postdoctoral Fellow; Prevention; Preventive Medicine; Primary Prevention; Process; Protein C; Publishing; Randomized; Range; Renal function; Research; Research Activity; Research Personnel; Risk; Risk Assessment; Risk Estimate; Risk Factors; Sample Size; Scientist; Smoking; Source; System; Thrombosis; Time; Training; United States National Institutes of Health; Vitamin B Complex; Vitamin E; Woman; Women' s Health; abstracting; aged; base; cardiovascular disorder prevention; cardiovascular risk factor; career; cohort; cost; design; dietary antioxidant; follow-up; interest; lipid metabolism; men; middle age; modifiable risk; non-diabetic; novel; programs; prospective; repository; skills

DESCRIPTION (provided by applicant): This project will prepare the candidate, Dr. Aruna Pradhan, for a career as an independent clinical scientist in cardiovascular epidemiology with a focus on risk assessment of peripheral arterial disease (PAD), her area of scientific interest. At the time of award activation, Dr. Pradhan will be a board eligible cardiologist having completed her fellowship training at the Brigham and Women's Hospital (BWH), Boston. Her post-doctoral research activities have been undertaken in the Center for Cardiovascular Disease Prevention within the Division of Preventive Medicine, BWH. The Center provides a scientifically productive environment for the support of junior investigators in the conduct of population-based epidemiologic research. The applicant proposes a 5-year program of research that will prospectively evaluate novel and traditional risk factors for PAD in women, among whom limited epidemiologic data exist. The risk factors to be examined may be categorized into one of three groups: novel biomarkers, traditional and behavioral cardiovascular risk factors, and dietary influences. Employing a prospective cohort design, analyses will be conducted in the Women's Health Study of 39,876 healthy middle-aged American women. The long-term follow-up and high quality covariate data in this cohort offer a unique opportunity to study, in a prospective manner, potentially modifiable risk factors for PAD in a large well-characterized population of women. At the conclusion of the award period, Dr. Pradhan will have acquired advanced epidemiologic skills and expertise in the study of PAD which will enable her to independently conduct research in prevention and treatment of this disease. This proposal seeks to evaluate the association between a broad range of emerging and traditional risk factors and the development of atherosclerosis in the lower extremity arterial system among American women. While prior limited data are available pertaining to these risk factors in men, information with regard to risk factor relationships in women are extremely sparse. Specific exposures of interest include blood based biomarkers, traditional cardiovascular risk factors such as diabetes, obesity, and elevated blood pressure, behavioral risk factors such as smoking and physical inactivity, and dietary influences such as fat, antioxidant, and carbohydrate intake. (End of Abstract)

描述（由申请人提供）： 该项目将为候选人Aruna Pradhan博士做好准备，成为心血管流行病学独立临床科学家的职业，重点是对外周动脉疾病（PAD）的风险评估，这是她的科学意义领域。在激活奖励时，Pradhan博士将是一名合格的心脏病专家，他在波士顿的Brigham and妇女医院（BWH）完成了奖学金培训。她的博士后研究活动是在预防医学分区内的心血管疾病预防中心进行的。该中心为基于人群的流行病学研究提供了一个科学生产的环境，以支持初级研究人员的支持。申请人提出了一项为期5年的研究计划，该计划将前瞻性评估女性PAD的新颖和传统危险因素，其中包括流行病学数据有限。要检查的危险因素可以分为三组之一：新型生物标志物，传统和行为心血管危险因素以及饮食影响。采用前瞻性队列设计，将在39,876名健康中年妇女的妇女健康研究中进行分析。该队列中的长期随访和高质量的协变量数据为在大量良好的妇女人群中以前瞻性修改的危险因素进行研究提供了独特的机会。在奖励期结束时，Pradhan博士将在PAD研究中获得高级流行病学技能和专业知识，这将使她能够独立进行预防和治疗这种疾病的研究。该提案旨在评估美国妇女中下肢动脉系统中广泛的新兴和传统危险因素与动脉粥样硬化的发展之间的关联。虽然先前的有限数据与男性中的这些风险因素有关，但关于女性风险因素关系的信息极为稀疏。感兴趣的特定暴露包括基于血液的生物标志物，传统的心血管危险因素，例如糖尿病，肥胖和血压升高，行为危险因素，例如吸烟和身体不活跃，以及饮食影响，例如脂肪，抗氧化剂和碳水化合物的摄入量。 （抽象的结尾）