Novel and Traditional Risk Factors for Symptomatic PAD in Women

女性症状性 PAD 的新的和传统的危险因素

• 批准号: 7384412
• 负责人: Aruna Das Pradhan
• 金额: $ 13.64万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-20 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7384412
• 关键词: Alcohol consumption; Alteplase; American; Antigens; Antioxidants; Apolipoproteins; Apolipoproteins B; Area; Aspirin; Atherosclerosis; Award; Behavioral; Biological Markers; Blood; Blood Banks; Blood Pressure; Blood specimen; Body fat; Boston; C-reactive protein; Carbohydrates; Cardiovascular Diseases; Cardiovascular system; Carotenoids; Clinical; Controlled Clinical Trials; Creatinine; Cross-Sectional Studies; Data; Data Collection; Development; Diabetes Mellitus; Diet Modification; Dietary Fiber; Disease; Dose; Enrollment; Environment; Epidemiologic Studies; Epidemiology; Evaluation; Fatty acid glycerol esters; Fellowship; Fibrin fragment D; Fibrinogen; Folate; Foundations; Funding; Glycosylated hemoglobin A; Grant; Group Processes; Health Professional; High Density Lipoprotein Cholesterol; Homocysteine; Homocystine; Hospitals; Incidence; Inflammation; Intake; Intercellular adhesion molecule 1; Intermittent Claudication; Intervention; Knowledge; Life Style; Lipoprotein (a); Lipoprotein (a-); Low-Density Lipoproteins; Lower Extremity; Malignant Neoplasms; Measurement; Obesity; Operative Surgical Procedures; Participant; Patient Self-Report; Peripheral; Peripheral arterial disease; Physical activity; Placebo Control; Plasma; Population; Postdoctoral Fellow; Prevention; Preventive Medicine; Primary Prevention; Process; Protein C; Publishing; Randomized; Range; Renal function; Research; Research Activity; Research Personnel; Risk; Risk Assessment; Risk Estimate; Risk Factors; Sample Size; Scientist; Smoking; Source; System; Thrombosis; Time; Training; United States National Institutes of Health; Vitamin B Complex; Vitamin E; Woman; Women' s Health; aged; base; cardiovascular disorder prevention; cardiovascular risk factor; career; cohort; cost; design; dietary antioxidant; follow-up; interest; lipid metabolism; men; middle age; modifiable risk; non-diabetic; novel; programs; prospective; repository; skills

This project will prepare the candidate, Dr. Aruna Pradhan, for a career as an independent clinical scientist in cardiovascular epidemiology with a focus on risk assessment of peripheral arterial disease (PAD), her area of scientific interest. At the time of award activation, Dr. Pradhan will be a board eligible cardiologist having completed her fellowship training at the Brigham and Women's Hospital (BWH), Boston. Her post-doctoral research activities have been undertaken in the Center for Cardiovascular Disease Prevention within the Division of Preventive Medicine, BWH. The Center provides a scientifically productive environment for the support of junior investigators in the conduct of population-based epidemiologic research. The applicant proposes a 5-year program of research that will prospectively evaluate novel and traditional risk factors for PAD in women, among whom limited epidemiologic data exist. The risk factors to be examined may be categorized into one of three groups: novel biomarkers, traditional and behavioral cardiovascular risk factors, and dietary influences. Employing a prospective cohort design, analyses will be conducted in the Women's Health Study of 39,876 healthy middle-aged American women. The long-term follow-up and high- quality covariate data in this cohort offer a unique opportunity to study, in a prospective manner, potentially modifiable risk factors for PAD in a large well-characterized population of women. At the conclusion of the award period, Dr. Pradhan will have acquired advanced epidemiologic skills and expertise in the study of PAD which will enable her to independently conduct research in prevention and treatment of this disease. This proposal seeks to evaluate the association between a broad range of emerging and traditional risk factors and the development of atherosclerosis in the lower extremity arterial system among American women. While prior limited data are available pertaining to these risk factors in men, information with regard to risk factor relationships in women are extremely sparse. Specific exposures of interest include blood- based biomarkers, traditional cardiovascular risk factors such as diabetes, obesity, and elevated blood pressure, behavioral risk factors such as smoking and physical inactivity, and dietary influences such as fat, antioxidant, and carbohydrate intake.

该项目将为候选人Aruna Pradhan博士作为独立临床科学家的职业生涯做好准备， 心血管流行病学，重点是外周动脉疾病（PAD）的风险评估，她的领域 科学兴趣。在奖励激活时，Pradhan博士将成为符合董事会资格的心脏病专家， 在波士顿布里格姆妇女医院（BWH）完成了她的奖学金培训。她的博士后 研究活动已在心血管疾病预防中心进行， 预防医学部，BWH。该中心提供了一个科学的生产环境， 支持初级研究人员进行基于人群的流行病学研究。申请人 提出了一项为期5年的研究计划，将前瞻性地评估新的和传统的风险因素， 妇女的PAD，其中流行病学数据有限。要检查的风险因素可能是 分为三组：新的生物标志物，传统和行为心血管风险 因素和饮食影响。采用前瞻性队列设计，将在 女性健康研究：39，876名健康的美国中年女性长期跟踪和高- 该队列中的高质量协变量数据提供了一个独特的机会，以前瞻性的方式研究， 在大量特征明确的女性人群中，PAD的可改变风险因素。结束时 在获奖期间，Pradhan博士将获得先进的流行病学技能和专业知识， 这将使她能够独立进行预防和治疗这种疾病的研究。 该提案旨在评估广泛的新兴风险和传统风险之间的关联 美国人下肢动脉系统动脉粥样硬化的发病因素 妇女虽然先前关于男性这些风险因素的数据有限，但关于以下方面的信息 女性中与危险因素的关系非常稀少。特别关注的暴露包括血液- 基于生物标志物，传统的心血管危险因素，如糖尿病，肥胖，和血液 压力，行为风险因素，如吸烟和缺乏身体活动，以及饮食影响，如脂肪， 抗氧化剂和碳水化合物的摄入。