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Treament of Deep Vein Thrombosis of the Lower Extremities w/Low Dose Alteplase

Treament of Deep Vein Thrombosis of the Lower Extremities w/Low Dose Alteplase
小剂量阿替普酶治疗下肢深静脉血栓
批准号：
7593114
负责人：
mcdonald k horne
金额：
$0.5万
依托单位：
CLINICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7593114
关键词：
AlteplaseAnticoagulationChronicClinical TrialsCoagulation ProcessCytolysisDailyDeep Vein ThrombosisDoseEnrollmentExcisionGoalsHemorrhageInjection of therapeutic agentLeftLower ExtremityPatientsPelvisPeripheralPharmaceutical PreparationsPostphlebitic SyndromeProtocols documentationReportingResolutionRiskSafetySerious Adverse EventSymptomsTestingThrombolytic TherapyThrombosisThrombusTreatment ProtocolsVeinsVenousWeekdaythrombolysis

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英文摘要
Patients with deep vein thrombosis of the lower extremities andor pelvis are eligible for this protocol if their thrombosis has been symptomatic for no more than 14 days and if their bleeding risk is very low. They are hospitalized for 3-7 days for up to 4 daily injections of rtPA directly into their thrombi. Simultaneously they receive anticoagulation, which is continued for 6 months. Since the last report we have enrolled 4 patients, for a total of 11. Extensive thrombolysis had been achieved with low doses of alteplase in every patient, and there have been no serious adverse events. The protocol is approved for 21 patients.
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