Reproductive Success in Equids

马科动物的繁殖成功

• 批准号: 2897895
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2897895
• 关键词: Reproductive; Success; Equids

In long-lived species, recruitment is fundamental to population resilience. This applies to both wild populations and managed systems. In wild populations, poor recruitment can lead to long-term declines. In managed populations, poor reproductive directly impacts on production. This project will identify the mechanisms driving long term population decline and poor recruitment/reproduction. We will compare reproductive health, disease burden and nutrition in populations that are recruiting well versus populations that are recruiting poorly. Reproductive failure can occur from irregular cycling, failure of an embryo to implant, and pregnancy loss (resorption). Each is likely to have different environmental drivers. In humans irregular cycling is linked to poor condition, lack of body fat and high stress levels. Failure of embryos to implant is linked to micronutrient deficiency, lack of viability of embryos and external stressors (both social and environmental). Resorption/miscarriage linked to poor foetal viability and external stressors. To evaluate individual reproductive health, we will use biomarkers for reproductive hormones, nutrition status and immune/inflammation markers. We will use metagenomics to evaluate changes in microbiome, evaluate disease burden and assess diet quality and composition.

在长寿物种中，补充对种群恢复力至关重要。这适用于野生种群和管理系统。在野生种群中，不良的招募可能导致长期下降。在管理的种群中，生殖不良直接影响产量。该项目将确定导致种群长期下降和招募/繁殖不良的机制。我们将比较招募情况良好的人口与招募情况不佳的人口的生殖健康、疾病负担和营养。生殖失败可能发生在不规则的周期，胚胎植入失败和妊娠丢失（吸收）。每一种可能都有不同的环境驱动因素。在人类中，不规则的骑自行车与身体状况不佳，缺乏身体脂肪和高压力水平有关。胚胎植入失败与微量营养素缺乏，胚胎缺乏活力和外部压力（社会和环境）有关。吸收/流产与胎儿活力差和外部压力有关。为了评估个体生殖健康，我们将使用生殖激素、营养状况和免疫/炎症标志物的生物标志物。我们将使用宏基因组学来评估微生物组的变化，评估疾病负担并评估饮食质量和组成。