Training Grant in Cardiac and Vascular Cell Biology

心脏和血管细胞生物学培训补助金

• 批准号: 7221883
• 负责人: Meredith Bond
• 金额: $ 19.61万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7221883
• 关键词: Blood Vessels; Cardiac; Cellular biology; Grant; Training

DESCRIPTION (provided by applicant): This program provides interdisciplinary training in cardiac and vascular cell biology for pre- and postdoctoral students. The program emphasizes the functional properties of cardiac and vascular smooth muscle. Our primary faculty members are from 4 departments/divisions of the University of Maryland School of Medicine and the University of Maryland Biotechnology Institute. Reflecting the diversity of faculty backgrounds, the training opportunities are broad and include: the molecular determinants of cardiac and vascular smooth muscle function, molecular structure and function studies of cardiac and vascular smooth muscle proteins, the cell biology of the cytoskeleton and extracellular matrix of cardiac and vascular smooth muscle, the biophysical and physiological analysis of the function of individual cardiac and vascular smooth muscle cells and endothelial cells, and the biomechanical properties of whole tissues and intact organs. Our faculty enjoys a national and international reputation in the study of calcium homeostasis in cardiac and vascular smooth muscle. Our students receive training in these and a variety of related areas including the molecular and functional control of muscle gone expression with emphasis on the use of several complementary techniques to approach each question under investigation. The major aspects of the didactic training consists of two interdisciplinary courses on muscle biology, courses in molecular biology and functional genomics offered by the Center's faculty. We propose 4 predoctoral and 4 postdoctoral trainees for each year of the training program. Entering predoctoral trainees will have a solid background in biology, chemistry and/or physics, excellent GRE scores, research experience and strong letters of recommendation. Incoming postdoctoral trainees will have completed a solid Ph.D. thesis and have strong letters of recommendation. Trainees completing this program will be prepared to bring a wide range of methodological approaches to bear on basic questions in normal cardiac and vascular cell biology, on the underlying mechanisms responsible for a variety of cardiac and vascular pathologies, and on their possible cure and prevention. Therefore, the program fills a national need for expert investigators with multidisciplinary training who can focus on cardiac and vascular muscle biology.

描述（由申请人提供）： 该计划为博士前和博士后学生提供心脏和血管细胞生物学的跨学科培训。 该计划强调心脏和血管平滑肌的功能特性。 我们的主要教师来自马里兰州医学院和马里兰州生物技术研究所的4个部门/部门。 反映教师背景的多样性，培训机会广泛，包括：心脏和血管平滑肌功能的分子决定因素，心脏和血管平滑肌蛋白的分子结构和功能研究，心脏和血管平滑肌细胞骨架和细胞外基质的细胞生物学，对单个心脏和血管平滑肌细胞和内皮细胞的功能以及整个组织和完整器官的生物力学特性进行生物物理和生理分析。 我们的教师在心脏和血管平滑肌中钙稳态的研究方面享有国内和国际声誉。 我们的学生接受这些和各种相关领域的培训，包括肌肉表达的分子和功能控制，重点是使用几种互补技术来解决每个调查中的问题。 教学培训的主要方面包括两个跨学科的肌肉生物学课程，分子生物学课程和功能基因组学由中心的教师提供。 我们建议每年培训4名博士前和4名博士后学员。进入博士前培训生将有一个坚实的背景，生物学，化学和/或物理学，优异的GRE成绩，研究经验和强有力的推荐信。即将到来的博士后培训生将完成一个坚实的博士学位。论文，并有强有力的推荐信。 完成该计划的学员将准备带来广泛的方法论方法，以解决正常心脏和血管细胞生物学中的基本问题，负责各种心脏和血管病理的潜在机制，以及可能的治疗和预防。 因此，该计划填补了一个国家 需要经过多学科培训的专家研究人员，他们可以专注于心脏和血管肌肉生物学。