Training Grant in Cardiac and Vascular Cell Biology

心脏和血管细胞生物学培训补助金

• 批准号: 7899839
• 负责人: Meredith Bond
• 金额: $ 35.77万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7899839
• 关键词: Blood Vessels; Cardiac; Cellular biology; Grant; Training

DESCRIPTION (provided by applicant): This Training Program provides a high-quality interdisciplinary training experience for pre- and postdoctoral trainees in cardiovascular physiology and pathophysiology. Training includes molecular, cell and systems biology, with an emphasis on translational science. Our goal is to provide trainees with comprehensive, multi-faceted training in cardiac and vascular cell biology, imbued with a strong appreciation of the disease relevance of their research. Our 32 faculty mentors are from 13 basic and clinical departments and divisions in the School of Medicine (SOM), School of Nursing (SON) and Medical Biotechnology Center (MBC) of the University of Maryland Biotechnology Institute (UMBI). All senior faculty mentors are NIH-funded; our talented new junior faculty, are, themselves, closely mentored provide the next wave of mentors for the Training Program The Program brings together selected, motivated students and postdoctoral fellows. Training opportunities are broad and include: molecular determinants of cardiovascular function, structure and function studies of cardiac and vascular signaling pathways, including protein trafficking. In this renewal there is increased focus, on genetics of cardiovascular diseases, analysis of the function of individual cardiac and vascular cells, as well as the biomechanical properties of whole tissues and intact organs. With reorganization of graduate studies at the School of Medicine (SOM) under the umbrella Graduate Program in Life Sciences (GPILS), quality and number of TGE predoctoral applicants continues to increase. Institutional support for graduate education is outstanding, with an annual investment over $2M. GPILS also takes the lead in mentoring postdoctoral fellows (e.g. career seminars, grant writing workshops). The coursework for pre-doctoral trainees consists of an 8 credit Core Curriculum, interdisciplinary courses in muscle biology, molecular biology and functional genomics. Topics in Molecular Medicine, a newly plaimed course on cardiac pathophysiology, and a hands on course on cardiovascular fiinction. The Program provides the framework for a cross-discipline, interactive community of pre- and postdoctoral trainees. Postdoctoral fellows take two cardiovascular intensive courses for credit and join with predoctoral trainees in regular meetings to present work-in-progress, provide feedback on the program, attend and present at weekly lunch time research forums, a weekly journal clubs and Annual Research Retreat. A new Program Director, and new Steering Committee, and an External Advisory Committee (EAC) closely track progress of the trainees and the success of the overall Program. Trainees completing this program will be prepared to bring to bear a range of experimental approaches on basic questions in normal cardiac and vascular cell biology, on the underlying mechanisms responsible for cardiac and vascular pathologies, and on their possible cure and prevention.

项目描述（申请人提供）：本项目为心血管生理学和病理生理学的在读博士后提供高质量的跨学科培训体验。培训内容包括分子、细胞和系统生物学，重点是转化科学。我们的目标是为受训者提供全面、多方面的心脏和血管细胞生物学培训，培养他们对研究疾病相关性的强烈认识。我们的32位指导教师来自马里兰大学生物技术研究所（UMBI）医学院（SOM）、护理学院（SON）和医学生物技术中心（MBC）的13个基础和临床科室。所有高级教师导师均由美国国立卫生研究院资助；我们有才华的新青年教师，他们自己，受到密切指导，为培训计划提供下一波导师。该计划汇集了精选的，有动力的学生和博士后研究员。培训机会广泛，包括：心血管功能的分子决定因素，心脏和血管信号通路的结构和功能研究，包括蛋白质运输。在这一更新有增加的重点，心血管疾病的遗传学，单个心脏和血管细胞的功能分析，以及整个组织和完整器官的生物力学特性。随着医学院（SOM）在生命科学研究生课程（GPILS）下的研究生学习的重组，TGE博士预科申请人的质量和数量继续增加。机构对研究生教育的支持非常出色，每年的投资超过200万美元。GPILS还带头指导博士后（如职业研讨会、拨款写作研讨会）。博士预科生的课程包括8学分的核心课程，肌肉生物学、分子生物学和功能基因组学的跨学科课程。分子医学专题，一门新开设的关于心脏病理生理学的课程，以及一门关于心血管疾病的实践课程。该计划提供了一个跨学科的框架，博士生和博士后学员的互动社区。博士后要参加两门心血管强化课程以获得学分，并与博士前实习生一起定期开会，介绍正在进行的工作，提供项目反馈，参加每周午餐时间的研究论坛，每周的期刊俱乐部和年度研究静修。新的项目主任、新的指导委员会和外部咨询委员会（EAC）密切跟踪受训人员的进展和整个项目的成功。完成本课程的学员将准备在正常心脏和血管细胞生物学的基本问题，心脏和血管病理的潜在机制，以及可能的治疗和预防方面采取一系列实验方法。