Blood System in Coagulation and Vessel Disease

血液系统中的凝血和血管疾病

• 批准号: 7168691
• 负责人: Linda K Curtiss
• 金额: $ 43.98万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-07-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7168691
• 关键词: Blood; Coagulation Process; Disease; System

DESCRIPTION (provided by applicant): This training grant has been an excellent and productive program for 30 years. It will continue to provide the same high quality postdoctoral training in biomedical research in Blood Systems in Coagulation and Vessel Disease. This training grant will provide postdoctoral fellows the opportunity to train for two to three years in 24 different research programs whose Principal Investigators devote 100 percent of their time to basic research. TSRI has maintained its commitment to training the next generation of scientists, in part, by its active recruitment of postdoctoral fellows, all of whom have completed postgraduate degrees. These fellows continue their scientific training in TSRI's laboratories for a period of two to five years under the supervision of the senior scientific staff. They contribute to ongoing research inquiries and are named authors on numerous scientific publications. Trainees are recruited via multiple routes to attract as many candidates as possible from diverse ethnic, geographic and scientific disciplines. Study of cellular and soluble components of the vasculature is the unique cohesive theme of this NHLBI program. Cardiovascular disease and cancer are major public health issues. Functional aspects of hemostasis and blood vessel disease are studied in blood proteins, platelets, leukocytes and tissues. The common goal of the carefully chosen faculty is to understand at a basic molecular level how the vasculature functions to transport, regulate and protect the whole organism. This goal will be pursued through interdisciplinary collaborations among investigators in three different departments within the Institute. Special emphasis will be placed on use of new emerging disciplines including knock out and transgenic animals, intracellular signaling pathways, gene array approaches, proteomics and saturation mutagenesis. The success of this program has been excellent. The training experience is and will continue to be competitive and geared toward the development of self-directed researchers, yet will be enriched by cooperation and communication among scientists of diverse backgrounds. (End of Abstract)

描述（由申请人提供）： 30年来，这项培训补助金一直是一项出色而富有成效的计划。它将继续提供同样高质量的博士后培训，在凝血和血管疾病的血液系统的生物医学研究。该培训补助金将为博士后研究员提供在24个不同的研究项目中进行两到三年培训的机会，这些项目的主要研究人员将100%的时间用于基础研究。TSRI一直致力于培养下一代科学家，部分是通过积极招募博士后研究员，他们都已完成研究生学位。这些研究员在高级科学工作人员的监督下，在TSRI的实验室继续接受为期2至5年的科学培训。他们为正在进行的研究调查做出贡献，并在许多科学出版物上被命名为作者。通过多种途径征聘受训人员，以吸引尽可能多的来自不同族裔、地域和科学学科的候选人。血管系统的细胞和可溶性成分的研究是这个NHLBI计划的独特主题。心血管疾病和癌症是主要的公共卫生问题。在血液蛋白、血小板、白细胞和组织中研究止血和血管疾病的功能方面。精心挑选的教师的共同目标是在基本分子水平上了解血管系统如何发挥运输，调节和保护整个生物体的功能。这一目标将通过研究所内三个不同部门的研究人员之间的跨学科合作来实现。将特别强调使用新兴学科，包括敲除和转基因动物，细胞内信号传导途径，基因阵列方法，蛋白质组学和饱和诱变。该计划的成功是非常好的。培训经验是并将继续具有竞争力，并面向自我指导的研究人员的发展，但将通过不同背景的科学家之间的合作和交流来丰富。 (End摘要）