Non-invasive real-time modelling of biophysical and metabolic changes in airways disease

气道疾病生物物理和代谢变化的无创实时建模

基本信息

  • 批准号:
    2899496
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Studentship
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    未结题

项目摘要

Sampling breath can uncover vast quantities of information about the underlying metabolic state of the body occurring in an individual in real-time. Tools to measure breath metabolites therefore have the potential for monitoring of a wide range of airways diseases. Despite increasingly large-scale studies being conducted in the last ten years, a clinically relevant breath test based on exhaled volatile organic compounds VOCs) test has yet to be validated. One reason for this is the number of confounding factors that must be accounted for during breath collection which makes reproducing published results difficult. Recent work on breath holding, oral versus nasal breathing (Sukul et al. 2014, 2017) and time of day (Wilkinson et al. 2019) has highlighted the need for standardised sampling protocols. Fractional exhaled nitric oxide (FeNO) levels, which are routinely used in asthma diagnosis and monitoring, are highly affected by these physiological parameters and it is therefore likely that the level of breath VOCs is similarly impacted. This combination of complex biological and physiological factors makes it difficult to interpret measurements or to develop analysis techniques that account for these factors. Therefore, this project will use a combination of controlled experiments with human volunteers and patients with airway disease (e.g. asthma) at the North West Lung Centre (Manchester University Hospitals) as well computational modelling of the lung to create new sampling protocols and analysis tools. This will build upon similar approaches that have been used previously to account for flow-rate and diffusion on FeNO measurement in the breath (Conderelli et al. 2007) or multiple breath washout measurements (Whitfield et al. 2022).The student will collaborate with our industry partner Imspex Diagnostic Ltd. to measure exhaled breath online using ion mobility spectrometry and mass spectrometry. The student will then build on sampling expertise within the group to assess the impact of changes in lung physiology on exhaled metabolites and investigate the short- and long-term variation observed in an individual's breath profile. These results will contribute to the optimisation of an existing lung function model that uniquely incorporates realistic rendering of lung physiology and gas washout in order to determine the factors governing exhaled VOC concentrations in health and disease.Although not essential, it would be advantageous for the prospective
对呼吸进行采样可以实时发现大量关于个体体内潜在代谢状态的信息。因此,测量呼吸代谢物的工具具有监测各种呼吸道疾病的潜力。尽管近十年来进行了越来越多的大规模研究,但基于呼出的挥发性有机化合物(VOCs)测试的临床相关呼气测试尚未得到验证。其中一个原因是在呼吸收集过程中必须考虑的混杂因素的数量,这使得复制已发表的结果变得困难。最近关于屏气、口腔与鼻腔呼吸(Sukul等人,2014年,2017年)和一天中的时间(Wilkinson等人,2019年)的工作强调了标准化采样方案的必要性。通常用于哮喘诊断和监测的呼气一氧化氮分数(FeNO)水平受到这些生理参数的高度影响,因此呼气挥发性有机化合物(VOCs)水平可能也受到类似影响。这种复杂的生物和生理因素的结合使得解释测量结果或开发解释这些因素的分析技术变得困难。因此,该项目将结合人类志愿者和西北肺部中心(曼彻斯特大学医院)气道疾病(如哮喘)患者的对照实验,以及肺部的计算模型,以创建新的采样方案和分析工具。这将建立在先前用于解释呼吸中FeNO测量的流量和扩散的类似方法(Conderelli等人,2007)或多次呼气冲洗测量(Whitfield等人,2022)的基础上。该学生将与我们的行业合作伙伴Imspex诊断有限公司合作,使用离子迁移谱法和质谱法在线测量呼出气体。然后,学生将在小组内建立采样专业知识,以评估肺部生理变化对呼出代谢物的影响,并调查在个人呼吸剖面中观察到的短期和长期变化。这些结果将有助于优化现有的肺功能模型,该模型独特地结合了肺生理和气体冲刷的现实渲染,以确定控制健康和疾病中呼出VOC浓度的因素。虽然不是必须的,但对未来是有利的

项目成果

期刊论文数量(0)
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专利数量(0)

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其他文献

Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
  • DOI:
    10.1002/cam4.5377
  • 发表时间:
    2023-03
  • 期刊:
  • 影响因子:
    4
  • 作者:
  • 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
  • DOI:
    10.1186/s12889-023-15027-w
  • 发表时间:
    2023-03-23
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
  • 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
  • DOI:
    10.1007/s10067-023-06584-x
  • 发表时间:
    2023-07
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
  • 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
  • DOI:
    10.1186/s12859-023-05245-9
  • 发表时间:
    2023-03-26
  • 期刊:
  • 影响因子:
    3
  • 作者:
  • 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
  • DOI:
    10.1039/d2nh00424k
  • 发表时间:
    2023-03-27
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
  • 通讯作者:

的其他文献

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{{ truncateString('', 18)}}的其他基金

An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
  • 批准号:
    2901954
  • 财政年份:
    2028
  • 资助金额:
    --
  • 项目类别:
    Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
  • 批准号:
    2896097
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
  • 批准号:
    2780268
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
  • 批准号:
    2908918
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
  • 批准号:
    2908693
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
  • 批准号:
    2908917
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
  • 批准号:
    2879438
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
  • 批准号:
    2890513
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
  • 批准号:
    2879865
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
  • 批准号:
    2876993
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship

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基于深穿透拉曼光谱的安全光照剂量的深层病灶无创检测与深度预测
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