Translating an Efficaious HPV Vaccine into the Control of Cervical Cancer

将有效的 HPV 疫苗用于控制宫颈癌

• 批准号: 7336975
• 负责人: Sharon Margaret Bond
• 金额: $ 7.61万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7336975
• 关键词: Address; Adolescent; Adult; African American; Age; Age-Years; Anogenital venereal warts; Cancer Control; Centers for Disease Control and Prevention (U.S.); Cervical; Cervical cancer vaccine; Child; Communities; Data; Decision Making; Dose; Educational Intervention; Ensure; Ethnic group; Female; Female Adolescents; Focus Groups; Gardasil; General Population; Goals; Grant; Health Benefit; Human; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papillomavirus 11; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus 6; Incidence; Infection; Infection prevention; Interdisciplinary Study; Intervention; Latino; Malignant neoplasm of cervix uteri; Methodology; Modeling; Oncogenic; Papillomavirus; Parents; Perception; Population; Primary Prevention; Public Health; Qualifying; Qualitative Research; Rate; Research; Research Personnel; Teenagers; Testing; Translating; Treatment Protocols; United States Food and Drug Administration; Vaccinated; Vaccination; Vaccines; Virus-like particle; Work; base; cancer prevention; carcinogenesis; caucasian American; cervical cancer prevention; girls; low socioeconomic status; medically underserved; medically underserved population; novel; novel vaccines; preadolescence; prevent; programs; racial and ethnic; racial and ethnic disparities; vaccine delivery

DESCRIPTION (provided by applicant): The FDA approval in summer 2006 of an efficacious human papillomavirus (HPV) vaccine provides an unprecedented opportunity for the primary prevention of cervical cancer. However, little is known about how to effectively deliver this vaccine to those most likely to benefit from its use: medically underserved pre- adolescent females. To translate this breakthrough into reduced cervical cancer incidence rates in the underserved, we must first take steps to enhance the likelihood that medically underserved teen and preteen females receive the HPV vaccine. The objective of this proposal is to gain information to develop effective educational interventions and then develop the intervention. To achieve this objective, we propose to address the following specific aims: 1) To conduct formative, qualitative research to identify factors that act as barriers to vaccines in general and to HPV vaccination in particular in medically underserved communities, especially among parents and pre- adolescent and early adolescent females. 2) To plan and develop an educational intervention to enhance informed decision-making in underserved communities concerning HPV vaccine delivery to pre-adolescent/early adolescent females. Using focus group methodology, we will characterize similarities and differences in perception of HPV vaccination in multiple groups of African Americans, Latinos, and white Americans. Focus groups will be conducted among both adult community stakeholders and pre-adolescent/adolescent females to assess inter- generational differences in perceptions. Comparisons of results between racial/ethnic groups will allow us to determine the value of tailoring subsequent interventions. This project addresses a timely, novel research topic that is translational by disseminating a scientific breakthrough to the general population to advance the public's health. This work will be carried out by a highly-qualified interdisciplinary research team, will address racial/ethnic disparities in the burden of cervical cancer, and will form the basis for a subsequent R01 to test interventions that will ultimately contribute to a U.S. model for cervical cancer control. The quadrivalent human papillomavirus (HPV) vaccine has been shown to virtually prevent 70% of cervical cancers when given to preteen girls. Information about the vaccine and its utilization are critical components in making the prevention of cervical cancer a reality. Understanding barriers and misperceptions that underserved communities have concerning the vaccine and cervical cancer will enable researchers to develop and test educational interventions that are ethnically and culturally effective and that ultimately enable vaccine acceptance.

描述（由申请人提供）：FDA在2006年夏天批准了一种有效的人乳头瘤病毒（HPV）疫苗，为宫颈癌的一级预防提供了前所未有的机会。然而，人们对如何有效地将这种疫苗提供给最有可能从其使用中受益的人知之甚少：用途：医疗服务不足的青春期前女性。为了将这一突破转化为降低服务不足人群的宫颈癌发病率，我们必须首先采取措施，提高医疗服务不足的青少年和青春期前女性接受HPV疫苗的可能性。本建议的目的是获得信息，以制定有效的教育干预措施，然后制定干预措施。为了实现这一目标，我们建议解决以下具体目标：1）进行形成性、定性研究，以确定在医疗服务不足的社区，特别是在父母和青春期前和青春期早期女性中，作为疫苗接种障碍的因素。2)计划和制定教育干预措施，以加强服务不足社区关于向青春期前/青春期早期女性提供HPV疫苗的知情决策。使用焦点小组方法，我们将描述在非裔美国人，拉丁美洲人和白色美国人的多个群体的HPV疫苗接种的看法的相似性和差异。将在成年社区利益攸关方和青春期前/青春期女性中开展焦点小组活动，以评估代际观念的差异。种族/族裔群体之间的结果比较将使我们能够确定定制后续干预措施的价值。该项目解决了一个及时的，新颖的研究课题，通过向公众传播科学突破来促进公众健康。这项工作将由一个高素质的跨学科研究团队进行，将解决宫颈癌负担中的种族/民族差异，并将为随后的R 01测试干预措施奠定基础，这些干预措施最终将有助于美国宫颈癌控制模式。四价人乳头瘤病毒（HPV）疫苗已被证明可以预防70%的宫颈癌，当给予青春期前的女孩时。关于疫苗及其使用的信息是实现预防宫颈癌的关键组成部分。了解缺乏服务的社区对疫苗和宫颈癌的障碍和误解将使研究人员能够开发和测试在种族和文化上有效的教育干预措施，并最终使疫苗被接受。