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Sleep Therapy Headset for Improving Sleep Quality of Older Adults

改善老年人睡眠质量的睡眠治疗耳机

基本信息

批准号：
7218350
负责人：
Philip Bonello
金额：
$ 10.7万
依托单位：
TOPBULB.COM, LLC
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2008-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7218350
关键词：
Adult Affect Alzheimer&apos s Disease Chronic Circadian Rhythms Clinical Trials Controlled Environment Cornea Data Device Safety Devices Dose Effectiveness Elderly Empirical Research Eye Foundations Future Glare Goals Health Heating Knowledge Laboratories Lens (device)Light Lighting Literature Maintenance Marketing Measurement Measures Melatonin Modeling Optics Pattern Performance Pharmacological Treatment Phase Phototransduction Pliability Population Positioning Attribute Power Sources Procedures Production Purpose Quality of life Rate Reporting Research Research Personnel Rest Review Literature Safety Sleep Sleep Wake Cycle Sleep disturbances Source System Technology Testing Time Weight Work Writing awake base commercialization cost cost effective day design experience falls improved light treatment patient home care prototype response tool

项目摘要

DESCRIPTION (provided by applicant): Chronic sleep disturbances are experienced by 40% to 70% of the oldest people in the population, over 65 years. Light treatment devices are available in the market, but they are expensive, are generally glaring because they use inefficient light sources. Further, they require that users be seated in front of the device for at least 30-60 minutes, reducing compliance rates. The goal of this proposed project is to test the feasibility of an effective, comfortable light-treatment device to affect the circadian system, and improve sleep efficiency of older adults. It has now been established that controlled light-dark cycles can re-entrain the circadian patterns of older people to a more normal wake-sleep cycle (van Someren et al., 1997; Figueiro et al., 2002, 2005), consolidating their rest/activity rhythms and improving sleep efficiency at night. This can potentially delay transition to more controlled environment and reduce falls among older adults. In addition, the circadian system is maximally sensitive to blue light (Brainard et al., 2001; Thapan et al., 2001, Rea et al., 2005). This device will attempt to combine flexibility of use with an effective light source for the circadian system. If successful, this device can be used as a non- pharmacological tool to consolidate sleep and improve sleep efficiency in older people, including those with Alzheimer's disease (AD). Based upon knowledge on lighting technologies, the sleep and circadian scientific literature, and upon empirical research performed by researchers at Rensselaer, it is believed that a headset device using blue light emitting diodes can deliver the correct spectrum, intensity, and duration of light to robustly stimulate the circadian system without providing glare to the user. Six prototypes that can deliver light of the right intensity, spectrum, and duration at the correct circadian time to activate the circadian system will be constructed. The project team will perform literature review, calculations and measurements to document safety of the proposed light-treatment device. Finally, the project team will test whether blue light delivered to the eyes of adults 50+ years using the prototypes will stimulate their circadian systems at night. Blue light will be given to 8 subjects during the dark phase of the circadian cycle to clearly demonstrate their ability to suppress melatonin, which will be used as a surrogate measure of circadian system activation. Subjective responses will be gathered as to comfort and acceptability of wearing the prototype. Once it is shown that this device can be used to activate the circadian system of those 50+ years, clinical trials can be designed to test the effectiveness of this sleep therapy headset for improving sleep quality of older adults. Sleep therapy headset for improving sleep quality of older adults Chronic sleep disturbances are experienced by 40% to 70% of the oldest people in the population over 65 years, which is a rapidly growing segment of the population. The purpose of this proposal is to improve the health and quality of life of older people, by testing the feasibility of an effective, comfortable light-treatment device that can be used to consolidate the rest/activity rhythms of older adults, including those with Alzheimer's disease (AD). Positive results would form an important scientific foundation for home care and institutional procedures and technologies that demonstrably and reliably improve the quality of life for older people, including those with AD.

描述（由申请人提供）：65岁以上的老年人中有40%至70%患有慢性睡眠障碍。市场上有光处理设备，但价格昂贵，而且由于使用的是低效光源，所以通常都很刺眼。此外，它们要求用户坐在设备前至少30-60分钟，降低了依从率。这个项目的目标是测试一种有效的、舒适的光治疗设备的可行性，以影响昼夜节律系统，提高老年人的睡眠效率。现在已经确定，受控制的光-暗周期可以使老年人的昼夜节律模式重新进入更正常的觉醒-睡眠周期（van Someren et al., 1997; Figueiro et al., 2002, 2005），巩固他们的休息/活动节奏，提高夜间睡眠效率。这可能会延迟向更可控环境的过渡，并减少老年人的跌倒。此外，昼夜节律系统对蓝光最为敏感（Brainard等人，2001；Thapan等人，2001；Rea等人，2005）。该装置将尝试将使用的灵活性与昼夜节律系统的有效光源结合起来。如果成功，该装置可以作为一种非药物工具来巩固睡眠，提高老年人的睡眠效率，包括那些患有阿尔茨海默病（AD）的人。基于照明技术的知识，睡眠和昼夜节律科学文献，以及伦斯勒研究人员进行的实证研究，相信使用蓝光发射二极管的耳机设备可以提供正确的光谱，强度和持续时间，以强有力地刺激昼夜节律系统，而不会给用户带来眩光。将构建六个原型，这些原型可以在正确的昼夜节律时间内提供正确的强度，光谱和持续时间，以激活昼夜节律系统。项目团队将进行文献审查、计算和测量，以证明拟议的光处理设备的安全性。最后，项目团队将测试蓝光是否会在夜间刺激50岁以上成年人的眼睛。在昼夜节律周期的黑暗阶段，8名受试者被给予蓝光，以清楚地证明他们抑制褪黑激素的能力，褪黑激素将被用作昼夜节律系统激活的替代指标。将收集主观反应，以舒适和可接受的穿着原型。一旦证明这个设备可以用来激活50岁以上的昼夜节律系统，就可以设计临床试验来测试这个睡眠治疗耳机对改善老年人睡眠质量的有效性。65岁以上的老年人中有40%到70%的人患有慢性睡眠障碍，这是一个快速增长的群体。该提案的目的是通过测试一种有效、舒适的光疗设备的可行性，改善老年人的健康和生活质量，该设备可用于巩固老年人的休息/活动节奏，包括那些患有阿尔茨海默病（AD）的老年人。积极的结果将为家庭护理和机构程序和技术奠定重要的科学基础，这些程序和技术可明显可靠地改善老年人（包括老年痴呆症患者）的生活质量。