Interdisciplinary Training in Transplantation Biology

描述(由申请人提供)：移植是临床医学中一个迅速扩展、具有挑战性的领域，在治愈许多人类疾病方面具有巨大的潜力。该领域为基础科学家和临床医生之间的富有成效的互动提供了令人兴奋的机会。匹兹堡大学的斯塔兹尔移植研究所和医学院的院系提供了独特的学术环境，有利于对年轻的基础科学家和医生进行全面、广泛的移植生物学培训，重点是免疫学和细胞和分子病理学。我们提出了一个跨学科的研究计划，以培训研究生和博士后研究人员，以帮助确保训练有素的研究人员能够在学术界、工业和政府附属研究中担任领导角色。具有不同但互补的研究兴趣、卓有成效的合作成功记录和致力于培训年轻研究人员的参与教员将传授移植生物学方面的技能，包括免疫遗传学、缺血再灌注损伤的方面、抗原提呈细胞和T细胞生物学、耐受诱导、肝脏免疫学、移植传染病生物学、慢性排斥、复合组织移植、异体和异种识别的演变、异种移植和新的治疗免疫抑制药/方案。该培训计划的主要目标是培养优秀的、可能独立的研究人员，能够解决移植生物学中的基本问题，并配备适当的生存和职业发展技能。博士前实习生将从匹兹堡大学医学院跨学科生物医学研究生培训计划注册的研究生中挑选出来，这些研究生表示有兴趣追求移植生物学方面的博士研究。在最初一年为2名博士前实习生提供支持，在随后几年为4名实习生提供支持，分配给研究一年级、二年级、三年级或四年级的学生。拥有医学博士、博士或医学博士/博士学位的博士后实习生将根据其突出的潜力被挑选出来，并将得到为期2年的支持。请在最初一年为2名博士后实习生提供支助，并在随后几年为4名实习生提供支助。

DESCRIPTION (provided by applicant): Transplantation is a rapidly-expanding, challenging area of clinical medicine with great potential for the cure of many human diseases. This field provides exciting opportunities for the productive interaction between basic scientists and clinicians. The University of Pittsburgh's Starzl Transplantation Institute and Departments in the School of Medicine provide a unique academic environment conducive to the comprehensive, broad-based training of young basic scientists and physicians in transplantation biology with an emphasis on immunology and cell and molecular pathology. We propose an interdisciplinary research program to train graduate and postdoctoral researchers to help ensure that highly-trained investigators are available to assume leadership roles in academia, industry and government-affiliated research. Participating faculty with diverse but complementary research interests, a successful record of productive collaboration and a commitment to training young investigators, will impart skills in transplantation biology, including expertise in immunogenetics, aspects of ischemia-reperfusion injury, antigen-presenting cell and T cell biology, tolerance induction, liver immunology, biology of transplant infectious disease, chronic rejection, composite tissue transplantation, evolution of allo- and xenorecognition, xenotransplantation and novel therapeutic immunosuppressive agents/regimens. The principal goal of this training program is to produce outstanding, potentially independent investigators, able to address fundamental questions in transplantation biology and equipped with appropriate survival and career development skills. Predoctoral trainees will be selected from graduate students enrolled in the Interdisciplinary Biomedical Graduate Training Program at the University of Pittsburgh School of Medicine, who express interest in pursing PhD research in transplantation biology. Support is requested for 2 predoctoral trainees in the initial year and for 4 trainees in subsequent years, distributed between students in their 1st, 2nd, 3rd or 4th year of research. Postdoctoral trainees with MD, PhD, or MD/PhD degrees will be selected based on their outstanding potential and will be supported for 2 years. Support is requested for 2 postdoctoral trainees in the initial year, and for 4 trainees in subsequent years.