Interdisciplinary Training in Transplantation Biology

项目摘要/摘要 迫切需要提高对移植排斥和耐受的机制基础的了解，以及 将先进成果转化为临床，为尖端基础和翻译提供令人兴奋的机会 科学家。迫切需要培训计划，以便为下一代 移植研究人员。在强有力的机构支持下，匹兹堡大学医学院 (UPSOM)Starzl移植研究所(STI)提供独特的学术环境，具有出色的 翻译研究基地和文化，有利于强大而全面、基础广泛的青年人才培养 移植生物学的基础科学家和内科医生。我们成熟的跨学科培训 移植生物学计划(TPTB)与其他(成功的)培训计划有非常明确的区分 在UPSOM。我们的培训计划有助于确保训练有素的调查人员，高度专注于 移植，可以在学术界、工业界和政府附属机构担任领导角色 研究。我们的高成就和资金充足的参与教职员工，自上一届以来进一步加强 研究领导新人的续签申请，特别是在骨髓和肺移植方面， 卓有成效的合作记录和对培训年轻调查人员的坚定承诺。 专业知识包括免疫遗传学、缺血再灌注损伤、抗原提呈细胞、T细胞和B细胞生物学， 干细胞生物学，耐受诱导，肝脏免疫学，移植感染疾病，慢性排斥反应，同种异体 以及异种识别、异种移植和人类移植免疫学。我们培训的一个独特之处 该计划的研究范围从无脊椎动物的研究(赠款上的一名训练员是无脊椎动物方面的专家 异种人识别)和啮齿动物对非人类灵长类动物和人类的影响。我们的实习生有三个资助周期 非常成功，在领先的期刊上发表文章，并获得个人研究奖学金、认可 以及职业发展奖和教师职位。我们的目标是生产出出类拔萃的、潜在的 独立调查人员，非常熟悉移植中的基本和翻译问题 并具备适当的调查、生存和职业发展技能。博士前 学员是从微生物学和免疫学专业的研究生中挑选出来的。 UPSOM的跨学科生物医学毕业生培训计划，包括医学科学家 培训计划，寻求移植生物学博士学位。基于在三年中取得的成功 此培训补助金的前几个资助期以及合格申请者的可用性，我们请求支持 16年及以后几年的2名博士前实习生。具有医学博士、博士或双学位的博士后实习生 将根据其突出的潜力被选中，并支持2年。请求为%2提供支持 16年级及以后几年的博士后培训生。我们的培训人员坚定地致力于确保 任命代表人数不足的多样性群体的成员获得赠款。

PROJECT SUMMARY/ABSTRACT The pressing need to improve understanding of the mechanistic basis of transplant rejection and tolerance and to translate advances to the clinic, provides exciting opportunities for cutting-edge basic and translational scientists. There is a critical need for training programs that optimally prepare the next generation of transplantation researchers. With strong institutional support, the University of Pittsburgh School of Medicine (UPSOM) Starzl Transplantation Institute (STI) provides a unique academic environment, with an outstanding translational research base and culture, conducive to strong and comprehensive, broad-based training of young basic scientists and physicians in transplantation biology. Our established and proven Interdisciplinary Training Program in Transplantation Biology (TPTB) is very clearly delineated from other (successful) training programs at UPSOM. Our training program helps ensure that highly-trained investigators, strongly focused on transplantation, are available to assume leadership roles in academia, industry and government-affiliated research. Our highly-accomplished and well-funded participating faculty, further strengthened since our last renewal application by research leadership recruits, particularly in bone marrow and lung transplantation, have a very successful record of productive collaboration and strong commitment to training of young investigators. Expertise includes immunogenetics, ischemia-reperfusion injury, antigen-presenting cell, T and B cell biology, stem cell biology, tolerance induction, liver immunology, transplant infectious disease, chronic rejection, allo- and xenorecognition, xenotransplantation and human transplant immunology. A unique feature of our Training Program is that investigations range from those in invertebrates (a trainer on the grant is expert in invertebrate allorecognition) and rodents to non-human primates and humans. Over three funding cycles our trainees have been very successful, publishing in leading journals, and in obtaining individual research fellowships, recognition and career development awards and faculty positions. Our goal is to produce outstanding, potentially independent investigators, highly conversant with fundamental and translational questions in transplantation biology and equipped with appropriate investigational, survival and career development skills. Pre-doctoral trainees are selected from graduate students enrolled in the Program in Microbiology & Immunology and the Interdisciplinary Biomedical Graduate Training Program at UPSOM, including those in the medical scientist training program, who seek a PhD in transplantation biology. Based on successes achieved during the three previous funding periods of this Training Grant and the availability of well-qualified applicants, we request support of 2 pre-doctoral trainees in year 16 and subsequent years. Postdoctoral trainees with MD, PhD, or dual degrees will be selected based on their outstanding potential and supported for 2 years. Support is requested for 2 postdoctoral trainees in year 16 and subsequent years. Our training faculty are strongly committed to ensuring appointments of members of underrepresented diversity groups to the grant.