Interdisciplinary Training in Transplantation Biology

描述（由申请人提供）：移植是临床医学的一个快速扩展、具有挑战性的领域，具有治愈许多人类疾病的巨大潜力。这一领域为基础科学家和临床医生之间的富有成效的互动提供了令人兴奋的机会。匹兹堡大学的Starzl移植研究所和医学院的部门提供了一个独特的学术环境，有利于对年轻的基础科学家和医生进行全面，广泛的移植生物学培训，重点是免疫学和细胞和分子病理学。我们提出了一个跨学科的研究计划，以培养研究生和博士后研究人员，以帮助确保训练有素的调查人员可以在学术界，工业界和政府附属研究中担任领导角色。参与教师具有多样但互补的研究兴趣，富有成效的合作和培训年轻研究人员的承诺的成功记录，将传授移植生物学技能，包括免疫遗传学的专业知识，缺血再灌注损伤，抗原呈递细胞和T细胞生物学，耐受诱导，肝脏免疫学，移植感染性疾病，慢性排斥反应，复合组织移植，同种异体和异种识别、异种移植和新型治疗性免疫抑制剂/方案的进展。该培训计划的主要目标是培养优秀的，潜在的独立研究人员，能够解决移植生物学的基本问题，并配备适当的生存和职业发展技能。博士前学员将从匹兹堡大学医学院跨学科生物医学研究生培训计划的研究生中挑选，他们表示有兴趣从事移植生物学博士研究。要求在第一年为2名博士前学员提供支持，并在随后的几年为4名学员提供支持，这些学员分布在学生的第1，第2，第3或第4年的研究中。具有MD，PhD或MD/PhD学位的博士后培训生将根据其突出的潜力进行选择，并将获得2年的支持。第一年需要支助2名博士后受训人员，随后几年需要支助4名受训人员。

DESCRIPTION (provided by applicant): Transplantation is a rapidly-expanding, challenging area of clinical medicine with great potential for the cure of many human diseases. This field provides exciting opportunities for the productive interaction between basic scientists and clinicians. The University of Pittsburgh's Starzl Transplantation Institute and Departments in the School of Medicine provide a unique academic environment conducive to the comprehensive, broad-based training of young basic scientists and physicians in transplantation biology with an emphasis on immunology and cell and molecular pathology. We propose an interdisciplinary research program to train graduate and postdoctoral researchers to help ensure that highly-trained investigators are available to assume leadership roles in academia, industry and government-affiliated research. Participating faculty with diverse but complementary research interests, a successful record of productive collaboration and a commitment to training young investigators, will impart skills in transplantation biology, including expertise in immunogenetics, aspects of ischemia-reperfusion injury, antigen-presenting cell and T cell biology, tolerance induction, liver immunology, biology of transplant infectious disease, chronic rejection, composite tissue transplantation, evolution of allo- and xenorecognition, xenotransplantation and novel therapeutic immunosuppressive agents/regimens. The principal goal of this training program is to produce outstanding, potentially independent investigators, able to address fundamental questions in transplantation biology and equipped with appropriate survival and career development skills. Predoctoral trainees will be selected from graduate students enrolled in the Interdisciplinary Biomedical Graduate Training Program at the University of Pittsburgh School of Medicine, who express interest in pursing PhD research in transplantation biology. Support is requested for 2 predoctoral trainees in the initial year and for 4 trainees in subsequent years, distributed between students in their 1st, 2nd, 3rd or 4th year of research. Postdoctoral trainees with MD, PhD, or MD/PhD degrees will be selected based on their outstanding potential and will be supported for 2 years. Support is requested for 2 postdoctoral trainees in the initial year, and for 4 trainees in subsequent years.