Harvard Longwood Medical Area Training Grant in Transplantation

哈佛朗伍德医学区移植培训补助金

• 批准号: 7287540
• 负责人: John J Iacomini
• 金额: $ 14.45万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7287540
• 关键词: Area; Grant; Medical; Training; Transplantation

DESCRIPTION (provided by applicant): Transplantation is an exciting and rapidly expanding field with great potential for curing human disease. The purpose of this institutional training program is to provide opportunities for young scientists and physician scientists for training in a wide variety of topics related to basic research transplantation immunology with an emphasis on immunological mechanisms. To this end, we have developed a Harvard Longwood Medical Area wide combined training program in which a highly collaborative and productive group of faculty with diverse but complementary research interests, a record of collaboration, and a commitment to training young investigators will serve to mentor individuals committed to a career in transplantation biology. The faculty will provide pre- and postdoctoral trainees with the opportunity to receive training in topics related to transplantation immunology including tolerance, T cell activation, MHC structure and function, gene therapy, lymphocyte trafficking, bone marrow transplantation, vascular biology, stem cell biology, regulation of lymphocyte development, infectious disease, autoimmunity, islet transplantation, bioinformatics, and xenotransplantation. The major goal is to produce outstanding independent investigators capable of addressing fundamental questions in the field of transplantation. The experience and dedication of the faculty, as well as the research environment comprised of the major teaching hospital within the Harvard Longwood Medical Area and Harvard Medical School provide a unique environment in which this goal can be accomplished. Pre-doctoral trainees will be selected from the Immunology Program at Harvard University's Division of Medical Sciences based on their interest in pursuing dissertation research in the field of transplantation immunology. Support is requested for 1 pre-doctoral trainee in year 1 and 2 in all subsequent years, distributed between students in their 1st, 2nd 3rd, or 4th year of thesis research. Training for pre-doctoral students will take approximately 4 years. Postdoctoral trainees currently holding a degree of MD, PhD, or MD, PhD will be selected based on having outstanding potential to pursue a career in research and teaching and a commitment to independent investigation. Support is requested for 2 postdoctoral trainees in year 1 and 4 in years 2 through 5 of the training proposal. Training will require 3 years. Trainees will choose a primary research advisor from the participating training faculty that will oversee daily research endeavors of the trainee. All trainees will participate in an interactive environment comprised of formal course work, departmental and interdepartmental seminar series, journal club, and laboratory meetings. This interactive environment will insure that all trainees are exposed to a wide variety of disciplines and will help prepare them for an independent career in transplantation immunology, a field with direct relevance to human health.

描述(申请人提供)：移植是一个令人兴奋和迅速扩展的领域，在治愈人类疾病方面具有巨大的潜力。这一机构培训方案的目的是为年轻科学家和内科科学家提供机会，培训与基础研究、移植免疫学有关的各种主题，重点是免疫机制。为此，我们制定了哈佛大学朗伍德医学区范围的联合培训计划，在该计划中，具有不同但互补的研究兴趣、合作记录和致力于培训年轻研究人员的高度合作和富有成效的教职员工团队将帮助指导致力于移植生物学事业的个人。该学院将为博士后和博士后学员提供与移植免疫学相关的培训机会，包括耐受性、T细胞激活、MHC结构和功能、基因治疗、淋巴细胞贩运、骨髓移植、血管生物学、干细胞生物学、淋巴细胞发育调控、传染病、自身免疫、胰岛移植、生物信息学和异种移植。主要目标是培养优秀的独立调查人员，能够解决移植领域的基本问题。教职员工的经验和奉献精神，以及哈佛大学朗伍德医学区和哈佛医学院内主要教学医院组成的研究环境，为实现这一目标提供了独特的环境。博士前实习生将根据他们对移植免疫学领域的论文研究的兴趣，从哈佛大学医学部的免疫学项目中挑选出来。1名博士前实习生在第一年和第二年之后的所有年份都需要支持，分配给第一年、第二年、第三年或第四年的学生进行论文研究。对博士前学生的培训大约需要4年时间。目前拥有医学博士学位、博士学位或医学博士学位的博士后实习生将根据具有从事研究和教学事业的突出潜力以及致力于独立调查而被选中。要求在培训提案的第二年至第五年为第一年和第四年的2名博士后实习生提供支持。培训将需要3年时间。学员将从参与培训的教职员工中选择一名主要研究顾问，负责监督学员的日常研究工作。所有受训人员将参与一个由正式课程工作、部门间和部门间系列研讨会、期刊俱乐部和实验室会议组成的互动环境。这种互动环境将确保所有受训人员接触到各种各样的学科，并将帮助他们为在移植免疫学这一与人类健康直接相关的领域从事独立的职业生涯做好准备。