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INDUCTION OF TOLERANCE IN MACAQUES W/GENETICALLY ALTERED AUTOLOGOUS BONE MARROW

INDUCTION OF TOLERANCE IN MACAQUES W/GENETICALLY ALTERED AUTOLOGOUS BONE MARROW
用基因改造的自体骨髓诱导猕猴耐受
批准号:
7349531
负责人:
John J Iacomini
金额:
$3.5万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-05-01 至 2007-04-30

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have shown that genetic engineering of autologous stem cells to induce molecular chimerism can be used to establish B cell tolerance in mice. To determine whether a similar approach could be used in Rhesus macaques, we investigated whether induction of molecular chimerism could affect production of antibodies specific for the epitope Gal alpha1-3Gal beta 1-4GlcNAc-R (alpha Gal)
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