Harvard Longwood Medical Area Training Grant in Transplantation

描述（由申请人提供）：移植是一个令人兴奋和迅速扩大的领域，具有治愈人类疾病的巨大潜力。该机构培训计划的目的是为年轻科学家和医生科学家提供机会，以培训与基础研究移植免疫学相关的各种主题，重点是免疫机制。为此，我们已经开发了一个哈佛朗伍德医学区广泛的联合培训计划，其中具有不同但互补的研究兴趣，合作记录，并致力于培训年轻的研究人员的教师高度协作和富有成效的小组将有助于指导致力于移植生物学事业的个人。该学院将为博士前和博士后学员提供接受与移植免疫学相关主题培训的机会，包括耐受性，T细胞活化，MHC结构和功能，基因治疗，淋巴细胞运输，骨髓移植，血管生物学，干细胞生物学，淋巴细胞发育调节，传染病，自身免疫，胰岛移植，生物信息学和异种移植。主要目标是培养能够解决移植领域基本问题的杰出独立研究人员。教师的经验和奉献精神，以及由哈佛朗伍德医学区和哈佛医学院内的主要教学医院组成的研究环境，为实现这一目标提供了独特的环境。博士预科生将从哈佛大学医学部的免疫学项目中挑选，根据他们对移植免疫学领域的论文研究的兴趣。要求支持1年1和2在随后的所有年份，在他们的论文研究的第1，第2，第3或第4年的学生之间分布的博士前实习生。对博士生的培训大约需要4年。目前持有MD，PhD或MD，PhD学位的博士后学员将根据具有从事研究和教学事业的杰出潜力以及对独立调查的承诺进行选择。要求在培训提案的第1年和第2年至第5年为2名博士后学员提供支助。培训需要3年时间。学员将从参与培训的教师中选择一名主要研究顾问，负责监督学员的日常研究工作。所有学员将参加一个互动的环境，包括正式的课程工作，部门和部门间的研讨会系列，杂志俱乐部，和实验室会议。这种互动的环境将确保所有学员接触到各种各样的学科，并将帮助他们准备在移植免疫学，一个与人类健康直接相关的领域的独立职业生涯。

DESCRIPTION (provided by applicant): Transplantation is an exciting and rapidly expanding field with great potential for curing human disease. The purpose of this institutional training program is to provide opportunities for young scientists and physician scientists for training in a wide variety of topics related to basic research transplantation immunology with an emphasis on immunological mechanisms. To this end, we have developed a Harvard Longwood Medical Area wide combined training program in which a highly collaborative and productive group of faculty with diverse but complementary research interests, a record of collaboration, and a commitment to training young investigators will serve to mentor individuals committed to a career in transplantation biology. The faculty will provide pre- and postdoctoral trainees with the opportunity to receive training in topics related to transplantation immunology including tolerance, T cell activation, MHC structure and function, gene therapy, lymphocyte trafficking, bone marrow transplantation, vascular biology, stem cell biology, regulation of lymphocyte development, infectious disease, autoimmunity, islet transplantation, bioinformatics, and xenotransplantation. The major goal is to produce outstanding independent investigators capable of addressing fundamental questions in the field of transplantation. The experience and dedication of the faculty, as well as the research environment comprised of the major teaching hospital within the Harvard Longwood Medical Area and Harvard Medical School provide a unique environment in which this goal can be accomplished. Pre-doctoral trainees will be selected from the Immunology Program at Harvard University's Division of Medical Sciences based on their interest in pursuing dissertation research in the field of transplantation immunology. Support is requested for 1 pre-doctoral trainee in year 1 and 2 in all subsequent years, distributed between students in their 1st, 2nd 3rd, or 4th year of thesis research. Training for pre-doctoral students will take approximately 4 years. Postdoctoral trainees currently holding a degree of MD, PhD, or MD, PhD will be selected based on having outstanding potential to pursue a career in research and teaching and a commitment to independent investigation. Support is requested for 2 postdoctoral trainees in year 1 and 4 in years 2 through 5 of the training proposal. Training will require 3 years. Trainees will choose a primary research advisor from the participating training faculty that will oversee daily research endeavors of the trainee. All trainees will participate in an interactive environment comprised of formal course work, departmental and interdepartmental seminar series, journal club, and laboratory meetings. This interactive environment will insure that all trainees are exposed to a wide variety of disciplines and will help prepare them for an independent career in transplantation immunology, a field with direct relevance to human health.