Computational and Structural Biology in Biodefense

生物防御中的计算和结构生物学

• 批准号: 7274687
• 负责人: David G Gorenstein
• 金额: $ 10.35万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7274687
• 关键词: biodefense; structural biology

DESCRIPTION (provided by applicant): We will establish a multidisciplinary predoctoral and postdoctoral Training Program in Computational and Structural Biology in Biodefense, spanning the fields of biochemistry, biophysics, molecular biology, structural biology, bioinformatics, genomics, proteomics, database management, chemical biology, cell biology, immunology, virology, and pathology. The last 20 years have seen a remarkable resurgence of infectious diseases and the emergence of new ones such as AIDS and SARS, as well as the new threat from bioterrorism. Consequently, there is a critical need to train first-rate, imaginative, and creative scientists in this multidisciplinary field. Strong emphasis will be placed on cross-training in these fields. The opportunities to develop new vaccines, therapeutics, and diagnostics for biothreat agents and emerging or reemerging infectious diseases have never been greater, and the need to develop interdisciplinary training never more important than today. This training grant application requests support for six predoctoral and four postdoctoral trainees; each trainee will be supported for a period of two years. Together with the research and infrastructure and training support provided by the W. M. Keck Center for Computational Biology of the Gulf Coast Consortia as well as the Western Regional Center of Excellence in Biodefense and Emerging Infectious Diseases and the Galveston National Laboratory, this number will provide an adequate critical mass of trainees for the base of 32 mentors in the program, as each trainee will be required to participate in interdisciplinary research, with a primary mentor and a secondary co-mentor, one in structural, computational or chemical biology and the other in a biomedical field related to biodefense and infectious diseases. Part of the success of this program is the team-based, multi-disciplinary, multi-institutional groups of scientists that have worked together now for over 14 years, consisting of researchers at Baylor College of Medicine, Rice U., U. of Houston, U. of Texas HSC, Houston M. D. Anderson Cancer Ctr., and UTMB Galveston.

描述（由申请人提供）：我们将建立一个在生物障碍中计算和结构生物学领域的多学科和博士后培训计划，涵盖生物化学，生物物理学，分子生物学，结构生物学，结构生物学，生物信息学，生物信息学，基因组学，蛋白质组学，数据库管理学，化学生物学，化学生物学，化学生物学，化学生物学，病毒，病毒，病毒，病毒，病毒学，病毒，病毒学，病毒学。在过去的20年中，传染病以及艾滋病和SARS等新的疾病的出现以及生物恐怖主义的新威胁都引起了人们的显着复兴。因此，在这个多学科领域中训练一流，富有想象力和创造性科学家的迫切需要。在这些领域的交叉训练将非常重视。开发新疫苗，治疗剂和诊断剂的机会，以及新兴或重新出现的传染病从未有所更大，并且需要开发跨学科培训的需要，从来都不比今天更重要。这项培训赠款申请要求为六名五名和四名博士后学员提供支持；每个学员将得到两年的支持。以及W. M. Keck计算生物学中心提供的研究，基础设施和培训支持，以及西方的生物陷入困境和新兴的感染性疾病和新兴的感染性疾病和加尔维斯顿国家实验室的卓越区域卓越中心，这一数字将为每种培训者提供足够的培训者，以提供32个培训者的批量研究。导师和次要的联合学者，一个在结构，计算或化学生物学中，另一个在与生物障碍和传染病有关的生物医学领域中。该计划的成功的一部分是基于团队的多学科，多机构的科学家小组，这些组织已经合作了14年以上，由贝勒医学院的研究人员组成，赖斯，赖斯，美国休斯顿美国，美国德克萨斯州HSC，休斯敦M. D. Anderson M. D. Anderson Cancer CTR。和UTMB Galveston。