Physicochemical characterisation of oligonucleotides for therapeutic formulations

虽然寡核苷酸是很有前景的治疗药物，但它们的配方具有挑战性，因为它们在较高浓度下具有相当大且不可预测的粘度，这是通过注射给药的障碍。使用一系列的物理化学分析工具来研究分子间和分子内的相互作用，该项目旨在对寡核苷酸粘度与其物理化学性质的关系产生基本的理解，并应用这些知识来控制寡核苷酸配方粘度，使这些有前途的化合物作为注射药物的递送。

While oligonucleotides are promising therapeutics, their formulation is challenging because of their considerable and unpredictable viscosity at higher concentrations which is an obstacle to delivery by injection. Using a range of physicochemical analysis tools to study inter- and intramolecular interactions, this project aims to generate fundamental understanding of how oligonucleotide viscosity is related to their physicochemical properties and apply this knowledge to control oligonucleotide formulation viscosity, enabling delivery of these promising compounds as injectable medicines.