CNS Involvement in the HIV Population in Ethiopia: A Post-mortem Forensic Study

埃塞俄比亚首都亚的斯亚贝巴的艾滋病毒感染率预计约为15.6%，没有 有关于艾滋病毒和艾滋病毒相关疾病如何影响埃塞俄比亚人口中枢神经系统的信息。这个 这项前瞻性神经病理学研究的主要科学目标是确定频率和 亚的斯亚贝巴HIV尸检病例脑部中枢神经系统受累的独特特征 实现科学目标将：1)转让技术，以教育和培训病理学家 埃塞俄比亚将使用尸检材料诊断艾滋病毒和艾滋病毒的病理特征- 相关的中枢神经系统参与，2)创建记录艾滋病毒病理特征的永久资源 疾病不同阶段的患者，以及3)建立临床诊断的病理确认或 疑似艾滋病病毒。目标一：建立亚的斯亚贝巴大学医学院之间的协作系统 和圣地亚哥加州大学收集埃塞俄比亚人的尸检组织 1)确定艾滋病毒感染的百分比和2)艾滋病毒相关的中枢神经系统机会性感染和/或 肿瘤。目的II：确定HIV阳性患者中结核分枝杆菌侵犯中枢神经系统的频率 本研究描述了中枢神经系统结核的病理类型与HIV中枢神经系统病理的关系。为了这个 目的：死后中枢神经系统组织将从200例法医法医病理学成人尸检中收集 由亚的斯亚贝巴广泛的埃塞俄比亚人组成的案件，将包括 猝死和因既往疾病死亡。将对组织进行神经病理处理 诊断以确定艾滋病毒和艾滋病毒相关中枢神经系统的受累模式。描述以下内容的数据库 患者的人口统计，包括具有详细神经病理诊断的组织切片将是 建造的。这些研究将首次提供对自然的 埃塞俄比亚艾滋病毒神经病因史。加州大学的这项合作努力 圣地亚哥和亚的斯亚贝巴大学医学院将为增加 埃塞俄比亚的研究能力，为以下项目提供永久和可扩展的技术资源 对埃塞俄比亚医务人员进行有关艾滋病毒神经发病机制的教育。加深了对 艾滋病毒神经致病将有助于改善埃塞俄比亚艾滋病毒患者的治疗和管理。

HIV infection in Addis Ababa, the capital city of Ethiopia, is projected to be approximately 15.6% and no information exists on how HIV and HIV-related diseases impact the CNS of the Ethiopian population. The main scientific objectives of this prospective neuropathological study are to determine the frequency and unique characteristics of CNS involvement from the brains of HIV autopsy cases in Addis Ababa. Accomplishing the scientific objectives will: 1) transfer technology to educate and train pathologists in Ethiopia to use autopsy material for the diagnosis and pathological characterization of HIV and HIV- associated CNS involvement, 2) create a permanent resource for documenting pathological profiles of HIV patients at various stages of disease, and 3) establish pathological confirmation of clinical diagnosis or suspected HIV. AIM I: Establish collaborative system between Addis Ababa University School of Medicine and the University of California San Diego for the collection of autopsy tissues from the Ethiopian population to 1) determine the percentage of HIV infection and 2) HIV associated CNS opportunistic infections and/or neoplasms. AIM II: Determine the frequency of CNS involvement by M. tuberculosis in HIV+ patients from this study and describe pathological patterns of CNS tuberculosis in relation to HIV CNS pathology. For this purpose, post-mortem CNS tissues will be collected from 200 Medico-legal Forensic Pathology adult autopsy cases that consist of a broad cross-section of the Ethiopian population in Addis Ababa and will include both sudden deaths and deaths from pre-existing illness. Tissues will be processed for neuropathological diagnoses to determine patterns of HIV and HIV-associated CNS involvement. A database describing patient demographics, and including tissue sections with detailed neuropathological diagnoses will be constructed. These studies will provide for the first time neuropathological characterization of the natural history of HIV neuropathogenesis in Ethiopian. This collaborative effort between the University of California San Diego and Addis Ababa University School of Medicine will contribute to the overall goal of increased research capacity in Ethiopia by providing a permanent and expandable technological resource for the education of medical personnel in Ethiopia regarding HIV neuropathogenesis. Increased understanding of HIV neuropathogensis will contribute to the improved treatment and management of HIV patients in Ethiopia.