Cellular and Molecular Physiology of Organ Function

描述(申请人提供)：该培训计划于2002年完全重组，以应对后基因组时代生理学的演变。随着包括人类在内的各种生物的基因组测序，人们在理解复杂系统的细胞和分子构件方面取得了重大进展。该培训计划的重点是整合来自多个领域的信息，包括细胞生理学、分子生物学和遗传学、生物化学和蛋白质结构、药理学和生物物理学，以了解复杂系统是如何运作和调节的。我们的新课程“生理学与综合医学生物学”采用了“系统和综合生物学”的方法，并为加强我们的培训计划奠定了基础，该培训计划旨在培养有才华的学生综合生物功能的现代概念和技术。目标是让他们进入教学和研究的职业生涯，在那里他们可以为基础生物科学本身和人类健康做出重大贡献。细胞和分子生理学博士学位的候选人是从拥有理科学士或硕士学位，并在数学(和/或物理或化学)和生物学方面拥有坚实背景的学生中挑选出来的。来自12个部门的35名调查人员组成了培训人员。由于生物系统中的大多数整合过程依赖于膜功能，培训人员的重点是细胞和膜研究，包括：1)上皮功能；2)膜运输机制；3)神经科学，包括可兴奋的膜；4)蛋白质生物合成和细胞内运输；5)结构生物学；6)细胞和细胞内信号、细胞生长；7)肌肉和分子马达；8)心血管、代谢和运动生理学。在大多数这样的小组中，技术专长横跨器官生理学、膜生物物理学、生物化学、分子生物学和遗传学以及蛋白质结构。除了培训教师和他们的实验室外，为学员提供的设施包括耶鲁大学生物和生物医学科学(BBS)跨部门综合项目(BBS)的200多名教师，以及广泛的现代核心设施。

DESCRIPTION (provided by applicant): This Training Program was completely restructured in 2002 in response to the evolution of physiology in the post-genomic era. With the sequencing of the genomes of various organisms including the human, significant strides have been made towards understanding the cellular and molecular building blocks of complex systems. This training program focuses on integrating information from many fields including cell physiology, molecular biology and genetics, biochemistry and protein structure, pharmacology and biophysics to understand how complex systems function and are regulated. Our new track in "Physiology and Integrative Medical Biology" takes a "systems and integrative biology" approach and provides the foundation for strengthening our training program designed to educate talented students in the modern concepts and techniques of integrated biological function. The goal is to launch them into careers in teaching and research where they can contribute significantly to basic biological science per se and to human health. Candidates for the Ph.D. degree in Cellular & Molecular Physiology are selected from the pool of students with a bachelor's or master's degree in science and a firm background in mathematics (and/or physics or chemistry) and biology. 35 investigators from 12 departments constitute the training faculty. Because the majority of integrative processes in biological systems depend upon membrane function, the training faculty is focused in cellular and membrane research including: 1) epithelial function; 2) mechanisms of membrane transport; 3) neuroscience including excitable membranes; 4) protein biosynthesis & intracellular transport; 5) structural biology; 6) cellular and intracellular signaling, cell growth, 7) muscle and molecular motors, and 8) cardiovascular, metabolic, and exercise physiology. In most of these groups, technical expertise spans organ physiology, membrane biophysics, biochemistry, and molecular biology and genetics, and protein structure. In addition to the training faculty and their laboratories, the facilities available to trainees include the more than 200 faculty in the interdepartmental Combined Program in the Biological and Biomedical Sciences (BBS) at Yale, as well as a broad range of modern core facilities.