Cellular and Molecular Physiology of Organ Function

器官功能的细胞和分子生理学

• 批准号: 7890914
• 负责人: EMILE L BOULPAEP
• 金额: $ 4.39万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7890914
• 关键词: Molecular; Organ; Physiology

DESCRIPTION (provided by applicant): This Training Program was completely restructured in 2002 in response to the evolution of physiology in the post-genomic era. With the sequencing of the genomes of various organisms including the human, significant strides have been made towards understanding the cellular and molecular building blocks of complex systems. This training program focuses on integrating information from many fields including cell physiology, molecular biology and genetics, biochemistry and protein structure, pharmacology and biophysics to understand how complex systems function and are regulated. Our new track in "Physiology and Integrative Medical Biology" takes a "systems and integrative biology" approach and provides the foundation for strengthening our training program designed to educate talented students in the modern concepts and techniques of integrated biological function. The goal is to launch them into careers in teaching and research where they can contribute significantly to basic biological science per se and to human health. Candidates for the Ph.D. degree in Cellular & Molecular Physiology are selected from the pool of students with a bachelor's or master's degree in science and a firm background in mathematics (and/or physics or chemistry) and biology. 35 investigators from 12 departments constitute the training faculty. Because the majority of integrative processes in biological systems depend upon membrane function, the training faculty is focused in cellular and membrane research including: 1) epithelial function; 2) mechanisms of membrane transport; 3) neuroscience including excitable membranes; 4) protein biosynthesis & intracellular transport; 5) structural biology; 6) cellular and intracellular signaling, cell growth, 7) muscle and molecular motors, and 8) cardiovascular, metabolic, and exercise physiology. In most of these groups, technical expertise spans organ physiology, membrane biophysics, biochemistry, and molecular biology and genetics, and protein structure. In addition to the training faculty and their laboratories, the facilities available to trainees include the more than 200 faculty in the interdepartmental Combined Program in the Biological and Biomedical Sciences (BBS) at Yale, as well as a broad range of modern core facilities.

描述（由申请人提供）：该培训计划于 2002 年针对后基因组时代生理学的演变进行了彻底重组。随着包括人类在内的各种生物体的基因组测序，在理解复杂系统的细胞和分子构建块方面已经取得了重大进展。该培训计划侧重于整合细胞生理学、分子生物学和遗传学、生物化学和蛋白质结构、药理学和生物物理学等多个领域的信息，以了解复杂系统的功能和调节方式。我们的“生理学和综合医学生物学”新课程采用“系统和综合生物学”方法，为加强我们的培训计划奠定了基础，该计划旨在教育有才华的学生了解综合生物功能的现代概念和技术。目标是让他们进入教学和研究领域，为基础生物科学本身和人类健康做出重大贡献。博士候选人细胞与分子生理学学位是从具有科学学士或硕士学位以及数学（和/或物理或化学）和生物学坚实背景的学生中选拔的。 培训师资队伍由来自12个部门的35名研究人员组成。由于生物系统中的大多数整合过程都依赖于膜功能，因此培训人员专注于细胞和膜研究，包括：1）上皮功能； 2）膜运输机制； 3）神经科学，包括可兴奋膜； 4）蛋白质生物合成和细胞内运输； 5）结构生物学； 6) 细胞和细胞内信号传导、细胞生长，7) 肌肉和分子马达，以及 8) 心血管、代谢和运动生理学。在这些小组中的大多数中，技术专长涵盖器官生理学、膜生物物理学、生物化学、分子生物学和遗传学以及蛋白质结构。除了培训教师及其实验室外，供学员使用的设施还包括耶鲁大学生物与生物医学科学 (BBS) 跨部门联合项目的 200 多名教师，以及各种现代化核心设施。