Genomics of antiepileptic drug-induced Stevens Johnson syndrome

抗癫痫药物引起的史蒂文斯约翰逊综合征的基因组学

• 批准号: nhmrc : 1103979
• 负责人: Dr Slavé Petrovski
• 金额: $ 34.17万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genomics-antiepileptic-drug-johnson-syndrome/662712
• 关键词: Genomics; antiepileptic; drug; induced; Stevens

Epilepsy affects 3% of people. Severe skin reactions to anti-epileptic drugs are unpredictable and potentially fatal. This project aims to better understand the complex genetic architecture of these reactions using the latest sequencing platforms applied to a unique collection of samples, followed by functional analysis. The findings will enhance the practice of precision medicine in epilepsy treatment, shed light on the mechanisms of these reactions, and inform better drug design in the future.

癫痫影响了3%的人。抗癫痫药物的严重皮肤反应是不可预测的，可能致命。该项目旨在更好地了解这些反应的复杂遗传结构，使用最新的测序平台应用于独特的样本集合，然后进行功能分析。这些发现将加强精准医学在癫痫治疗中的实践，阐明这些反应的机制，并为未来更好的药物设计提供信息。