Intramyocellular Lipid: Effects of Race and Diet

肌细胞内脂质：种族和饮食的影响

• 批准号: 7268087
• 负责人: JEANINE B ALBU
• 金额: $ 27.43万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7268087
• 关键词: Address; Adipose tissue; Affect; African American; Age; Biological Factors; Body Composition; Calories; Carbohydrates; Caucasians; Caucasoid Race; Condition; Country; Data; Deposition; Development; Diabetes Mellitus; Diet; Dietary Fats; Epidemic; Euglycemic Clamping; Fatty acid glycerol esters; Genetic; Glucose Clamp; Image; Imaging Techniques; Incidence; Infiltration; Insulin Resistance; Knowledge; Lead; Lipids; Literature; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Metabolic; Metabolism; Minority; Morbidity - disease rate; Muscle; Muscle Cells; National Health and Nutrition Examination Survey; Non-Insulin-Dependent Diabetes Mellitus; Numbers; Obesity; Persons; Physiology; Play; Population; Premenopause; Prevalence; Prevention; Protons; Public Health; Race; Research; Research Design; Risk; Risk Factors; Role; Sampling; Skeletal Muscle; Socioeconomic Status; Subgroup; Techniques; Training; United States; United States National Institutes of Health; Visceral; Weight; Woman; design; insulin sensitivity; intravenous glucose tolerance test; non-diabetic; novel strategies; racial difference; response; trait

DESCRIPTION (provided by applicant): Obesity and its co-morbidities continue to be a growing problem in this country. This is particularly so in African Americans and within this group, in women. Insulin resistance is one co-morbidity associated with obesity and is found to a greater degree in African Americans compared to Caucasians. Intramyocellular Lipids (IMCL- the fat within the myocytes) have been shown to be inversely related to a person's insulin sensitivity (SI). To date, it is not known if racial differences exist in IMCL content or whether it plays a role in the increased insulin resistance in African Americans. We have shown that African American women have increased skeletal muscle volume. The skeletal muscle in African American women may have a greater amount of IMCL, which can explain the greater degree of insulin resistance. We propose to explore aspects of muscle physiology and metabolism to identify if racial differences exist 1) in IMCL content and how this relates to SI; 2) in IMCL content and SI response to manipulations of fat and carbohydrate content of eucaloric diets. To answer these questions we propose to study lean and obese, pre-menopausal, non- diabetic African Americans and Caucasians women using 1) proton magnetic resonance spectroscopy (1H MRS) at baseline and after low and high fat diets, 2) frequently sampled intravenous glucose tolerance test at baseline and 3) hyperinsulinemic-euglycemic clamps after low and high fat diets. These studies will help in the understanding of the mechanisms of increased insulin resistance in the African American population. This is an important public health problem and results arising from the proposed studies may to lead to the development of new approaches for the treatment of this condition and prevention of related illnesses such as type 2 diabetes in African Americans. In this regard these studies may help to identify mechanisms for race-ethnic disparities in the incidence of type 2 diabetes mellitus and therefore respond to the NIH PA number 04-074.

描述（由申请人提供）：肥胖及其合并症在这个国家继续成为一个日益严重的问题。在非裔美国人和这个群体中的女性中尤其如此。胰岛素抵抗是一种与肥胖相关的合并症，与白种人相比，非裔美国人的胰岛素抵抗程度更高。肌细胞内脂质（IMCL-肌细胞内的脂肪）已被证明与一个人的胰岛素敏感性（SI）呈负相关。迄今为止，尚不清楚IMCL含量是否存在种族差异，也不清楚它是否在非裔美国人胰岛素抵抗增加中起作用。我们发现非裔美国女性的骨骼肌体积增加了。非裔美国妇女的骨骼肌可能有更多的IMCL，这可以解释更大程度的胰岛素抵抗。我们建议探索肌肉生理学和代谢方面，以确定是否存在种族差异：1)IMCL含量及其与SI的关系；2) IMCL含量和SI对高热量饮食中脂肪和碳水化合物含量的响应。为了回答这些问题，我们建议使用质子磁共振波谱（1H MRS）在基线和低脂肪饮食和高脂肪饮食后进行研究，2)基线时频繁采样静脉葡萄糖耐量试验，3)在低脂肪饮食和高脂肪饮食后使用高胰岛素-正糖钳。这些研究将有助于理解非裔美国人胰岛素抵抗增加的机制。这是一个重要的公共卫生问题，拟议研究的结果可能会导致开发治疗这种疾病和预防非裔美国人2型糖尿病等相关疾病的新方法。在这方面，这些研究可能有助于确定2型糖尿病发病率的种族差异机制，从而响应NIH PA号04-074。