Developing A Structural Biology Driven Approach To Biofilm Control And Management.

生物膜受细胞内次级信使c-二- gmp的浓度控制。两个有联系的博士讨论了多结构域蛋白在生物膜的管理和控制中的作用。本博士开发了一种新的结构生物学方法来研究配体控制的生物膜分散中的调节多结构域蛋白。与相关博士一起开发特定方法来影响已知控制运动和分散的多结构域蛋白质。这两个相互联系的博士致力于跨发现、动态分子系统和目标验证的整合。

Biofilms are controlled by the intracellular concentration of the secondary messenger c-di-GMP. Two linked PhDs address the role of multi-domain proteins as toggle switches in the management and control of biofilms. This PhD develops a novel structural biology approach to studying ligand controlled regulatory multi-domain proteins in biofilm dispersal. Together with the linked PhD that develop specific methods to influence multi-domain proteins known to control motility and dispersal. The two linked PhDs engage to integrate across discovery, dynamic molecular systems, and validation of targets.