Developing A Structural Biology Driven Approach To Biofilm Control And Management.

生物膜由第二信使c-di-GMP的细胞内浓度控制。两个相连的博士学位解决了多结构域蛋白质在生物膜的管理和控制中作为切换开关的作用。这个博士学位开发了一种新的结构生物学方法来研究生物膜分散中配体控制的调节多结构域蛋白。与相关博士一起开发特定方法来影响已知控制运动和分散的多结构域蛋白质。这两个相互关联的博士致力于整合发现，动态分子系统和目标验证。

Biofilms are controlled by the intracellular concentration of the secondary messenger c-di-GMP. Two linked PhDs address the role of multi-domain proteins as toggle switches in the management and control of biofilms. This PhD develops a novel structural biology approach to studying ligand controlled regulatory multi-domain proteins in biofilm dispersal. Together with the linked PhD that develop specific methods to influence multi-domain proteins known to control motility and dispersal. The two linked PhDs engage to integrate across discovery, dynamic molecular systems, and validation of targets.