Developing A Structural Biology Driven Approach To Biofilm Control And Management.

生物膜由第二信使c-di-GMP的胞内浓度控制。两个相连的PHD解决了多域蛋白在生物膜管理和控制中作为触发开关的作用。这个PHD开发了一种新的结构生物学方法来研究生物被膜扩散中受配体控制的调节多域蛋白。与链接的PHD一起，开发出特定的方法来影响已知的控制运动和扩散的多域蛋白质。这两个相互关联的博士从事跨发现、动态分子系统和靶标验证的整合。

Biofilms are controlled by the intracellular concentration of the secondary messenger c-di-GMP. Two linked PhDs address the role of multi-domain proteins as toggle switches in the management and control of biofilms. This PhD develops a novel structural biology approach to studying ligand controlled regulatory multi-domain proteins in biofilm dispersal. Together with the linked PhD that develop specific methods to influence multi-domain proteins known to control motility and dispersal. The two linked PhDs engage to integrate across discovery, dynamic molecular systems, and validation of targets.