Germ Cell Development in the Postnatal Testis: the Key to Early Surgery to Prevent Infertility and Malignancy in Cryptorchidism

产后睾丸生殖细胞发育：早期手术预防隐睾不孕和恶性肿瘤的关键

• 批准号: nhmrc : 1049014
• 负责人: A/Pr Bridget Southwell
• 金额: $ 48.36万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/germ-cell-development-malignancy-cryptorchidism/112051
• 关键词: Germ; Cell; Development; Postnatal; Testis

The germ cells have been studied very extensively before birth or after puberty, but little is known about what happens shortly after birth. In children with undescended testes, early germ cell development is deranged, and this may be the key to find the right time for surgery to prevent subsequent infertility and risk of cancer. This project proposes some novel hypotheses to explain this and the studies aim to obtain the evidence to support surgery in the first 3-6 months of life..

生殖细胞在出生前或青春期后已被广泛研究，但对出生后不久发生的事情知之甚少。在患有隐睾的儿童中，早期生殖细胞发育紊乱，这可能是找到合适的手术时间以防止随后的不孕症和癌症风险的关键。该项目提出了一些新的假设来解释这一点，这些研究旨在获得支持在生命的前3-6个月进行手术的证据。