Postnatal germ cells are controlled by FSH during 'minipuberty' at 3-6 months, and deranged by cryptorchidism to cause seminoma and infertility

这项研究将探讨一种令人兴奋的可能性，即通过了解原始精子细胞在出生后睾丸中的行为，可能会消除患有隐睾的婴儿成年后患癌症和不孕的风险。这项研究将确定原始精子细胞的关键变化，包括它们的时间和激素的控制，因此在合适的时间进行手术+/-辅助激素治疗，以优化睾丸隐睾婴儿未来的精子功能。

This study will investigate the exciting possibility that the risk of cancer and infertility in adulthood in infants born with undescended testes might be obviated by understanding how primitive sperm cells behave in the postnatal testis. The study will define the key changes to the primitive sperm cells, including their timing and control by hormones, so surgery is done at the right time +/-accessory hormone treatment to optimise future sperm function for babies with undescended testes.