Regulation of Gastrulation by Gravin

Gravin 对原肠胚形成的调节

• 批准号: 7246620
• 负责人: DOUGLAS C WEISER
• 金额: $ 4.88万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7246620
• 关键词: Actins; Adult; Anterior; Binding; Biological; Cell Polarity; Cell membrane; Cells; Complex; Condition; Congenital Abnormality; Cytoskeleton; Data; Development; Embryo; Fellowship; Genetic Epistasis; Germ Layers; Gravin; Human; In Vitro; Individual; Laboratories; Lead; Link; MAPK8 gene; Molecular; Morphogenesis; Movement; Names; Neoplasm Metastasis; Neural Tube Defects; Pathway interactions; Plant Roots; Prevention; Process; Protein Kinase C; Regulation; Role; Scaffolding Protein; Series; Signal Transduction; Spinal Dysraphism; System; Techniques; Testing; Tumor Suppressor Proteins; Xenopus; Zebrafish; base; cell growth regulation; cell motility; cellular imaging; driving force; in vivo; insight; loss of function; migration; polarized cell; programs; research study; tumor progression

DESCRIPTION (provided by applicant): Proper control of cell migration and cell polarity is essential for proper vertebrate development. Inappropriate activation of developmental programs in an adult is linked to metastasis during tumor progression. Also, loss of proper cell migration during early development can lead to birth defect such as neural tube defects, including spina bifida. Thus, this proposal focuses on the establishment of cell polarity and cell migration during early development. A better understanding of the molecular control of cell migration during development, should lead to a better understanding of the root causes of birth defects and the mechanism of metastasis, and hopefully will aid in the prevention or treatment of these conditions.

描述（由申请人提供）：细胞迁移和细胞极性的正确控制对于脊椎动物的正确发育至关重要。成人发育程序的不当激活与肿瘤进展过程中的转移有关。此外，在早期发育过程中失去适当的细胞迁移可能会导致出生缺陷，例如神经管缺陷，包括脊柱裂。因此，该提案重点关注早期发育过程中细胞极性和细胞迁移的建立。更好地了解发育过程中细胞迁移的分子控制，应该可以更好地了解出生缺陷的根本原因和转移机制，并有望有助于预防或治疗这些疾病。