Cognitive Brain Activity: Aging and Dementia
认知大脑活动:衰老和痴呆
基本信息
- 批准号:7244250
- 负责人:
- 金额:$ 26.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-06-01 至 2011-04-30
- 项目状态:已结题
- 来源:
- 关键词:AgeAgingAlzheimer&aposs DiseaseBehavioralBiological MarkersBrainClinicalCognitiveConditionDataData SetDementiaDiagnosisDiagnosticDiscriminant AnalysisDiseaseEarly DiagnosisEarly InterventionEvent-Related PotentialsFosteringGoalsIndividualInterventionInvasiveJudgmentKnowledgeLettersMeasuresMemoryMethodsNeuropsychological TestsNumbersParticipantPatientsPatternProbabilityProcessRelative (related person)ResearchResourcesScoreScreening procedureShort-Term MemoryStandards of Weights and MeasuresStimulusStructureTestingVisualagedbaseclinical applicationdesignimplicit memoryimprovedmemory processmild neurocognitive impairmentresearch studystatisticssuccesstool
项目摘要
DESCRIPTION (provided by applicant): Based on brain Event-Related Potentials (ERP) obtained under tasks with designed memory demands, the aim is to improve understanding and foster early interventions by 1) developing non-invasive brain activity marker(s) for Alzheimer's disease (AD) early in its course, and 2) predicting with such marker(s) which patients with mild cognitive impairment (MCI) will go on to develop Alzheimer's disease. About half of MCI patients develop AD within a few years. The overall goal is to determine early enough which patients might benefit from interventions and to understand better the brain functions altered in these diseases. We record ERP's while participants perform two simple cognitive tasks. In each of these tasks, ERP components differ under conditions which demand different use of memory and processing resources. The two tasks are (1) a number-letter paradigm that involves comparisons of numbers or of letters within each trial of 4 sequential stimuli (working memory); and (2) a pattern paradigm which involves symmetry judgments of visual patterns, some of which are repeated over trials (implicit memory). The research entails comparison of tasks-related ERPs of MCI patients, AD patients early in the course of AD, and appropriately aged controls. Multivariate statistics are used to measure the ERP components and to develop functions that discriminate among the subject groups and predict AD among the MCI patients.
描述(申请人提供):基于在具有设计的记忆需求的任务下获得的脑事件相关电位(ERP),目的是通过1)开发阿尔茨海默病(AD)早期的非侵入性脑活动标记物,和2)用这些标记物预测哪些轻度认知障碍(MCI)患者将继续发展为阿尔茨海默病。大约一半的MCI患者在几年内发展为AD。总体目标是尽早确定哪些患者可能从干预中受益,并更好地了解这些疾病中改变的大脑功能。当参与者执行两个简单的认知任务时,我们记录ERP。在这些任务中,ERP组件在需要不同使用内存和处理资源的条件下有所不同。这两个任务是(1)数字-字母范式,涉及4个连续刺激的每次试验中的数字或字母的比较(工作记忆);和(2)模式范式,涉及视觉模式的对称性判断,其中一些在试验中重复(内隐记忆)。本研究比较了MCI患者、AD早期患者和相应年龄对照组的任务相关ERP。多变量统计被用来测量ERP组件和开发功能,区分受试者群体和预测AD MCI患者之间。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ROBERT M CHAPMAN其他文献
ROBERT M CHAPMAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ROBERT M CHAPMAN', 18)}}的其他基金
Brain ERPs to Assess Emotional Function in Normal Aging and MCI/AD
大脑 ERP 评估正常衰老和 MCI/AD 中的情绪功能
- 批准号:
10553655 - 财政年份:2020
- 资助金额:
$ 26.13万 - 项目类别:
AD Pilot Clinical Trials: Spatiotemporal Brain ERP Measures
AD 试点临床试验:时空大脑 ERP 测量
- 批准号:
8529436 - 财政年份:2012
- 资助金额:
$ 26.13万 - 项目类别:
AD Pilot Clinical Trials: Spatiotemporal Brain ERP Measures
AD 试点临床试验:时空大脑 ERP 测量
- 批准号:
8369846 - 财政年份:2012
- 资助金额:
$ 26.13万 - 项目类别:
ELECTRICAL BRAIN ACTIVITY AND INFORMATION PROCESSING
脑电活动和信息处理
- 批准号:
2245027 - 财政年份:1987
- 资助金额:
$ 26.13万 - 项目类别:
ELECTRICAL BRAIN ACTIVITY AND INFORMATION PROCESSING
脑电活动和信息处理
- 批准号:
3378994 - 财政年份:1987
- 资助金额:
$ 26.13万 - 项目类别:
ELECTRICAL BRAIN ACTIVITY AND INFORMATION PROCESSING
脑电活动和信息处理
- 批准号:
3378991 - 财政年份:1987
- 资助金额:
$ 26.13万 - 项目类别:
相似海外基金
Interplay between Aging and Tubulin Posttranslational Modifications
衰老与微管蛋白翻译后修饰之间的相互作用
- 批准号:
24K18114 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
EMNANDI: Advanced Characterisation and Aging of Compostable Bioplastics for Automotive Applications
EMNANDI:汽车应用可堆肥生物塑料的高级表征和老化
- 批准号:
10089306 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Collaborative R&D
The Canadian Brain Health and Cognitive Impairment in Aging Knowledge Mobilization Hub: Sharing Stories of Research
加拿大大脑健康和老龄化认知障碍知识动员中心:分享研究故事
- 批准号:
498288 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Operating Grants
Baycrest Academy for Research and Education Summer Program in Aging (SPA): Strengthening research competencies, cultivating empathy, building interprofessional networks and skills, and fostering innovation among the next generation of healthcare workers t
Baycrest Academy for Research and Education Summer Program in Aging (SPA):加强研究能力,培养同理心,建立跨专业网络和技能,并促进下一代医疗保健工作者的创新
- 批准号:
498310 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Operating Grants
関節リウマチ患者のSuccessful Agingに向けたフレイル予防対策の構築
类风湿性关节炎患者成功老龄化的衰弱预防措施的建立
- 批准号:
23K20339 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Life course pathways in healthy aging and wellbeing
健康老龄化和福祉的生命历程路径
- 批准号:
2740736 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Studentship
NSF PRFB FY 2023: Connecting physiological and cellular aging to individual quality in a long-lived free-living mammal.
NSF PRFB 2023 财年:将生理和细胞衰老与长寿自由生活哺乳动物的个体质量联系起来。
- 批准号:
2305890 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Fellowship Award
I-Corps: Aging in Place with Artificial Intelligence-Powered Augmented Reality
I-Corps:利用人工智能驱动的增强现实实现原地老龄化
- 批准号:
2406592 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Standard Grant
McGill-MOBILHUB: Mobilization Hub for Knowledge, Education, and Artificial Intelligence/Deep Learning on Brain Health and Cognitive Impairment in Aging.
McGill-MOBILHUB:脑健康和衰老认知障碍的知识、教育和人工智能/深度学习动员中心。
- 批准号:
498278 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Operating Grants
Welfare Enhancing Fiscal and Monetary Policies for Aging Societies
促进老龄化社会福利的财政和货币政策
- 批准号:
24K04938 - 财政年份:2024
- 资助金额:
$ 26.13万 - 项目类别:
Grant-in-Aid for Scientific Research (C)