Brain ERPs to Assess Emotional Function in Normal Aging and MCI/AD

大脑 ERP 评估正常衰老和 MCI/AD 中的情绪功能

• 批准号: 10553655
• 负责人: ROBERT M CHAPMAN
• 金额: $ 38.57万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553655
• 关键词: 3-Dimensional; Address; Adult; Affect; Affective; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Appearance; Area; Attention; Behavioral; Behavioral Mechanisms; Brain; Clinical; Cognition; Cognition Disorders; Cognitive; Data; Dementia; Development; Dimensions; Disease; Elderly; Electrophysiology (science); Emotional; Emotions; Event-Related Potentials; Experimental Designs; Functional disorder; Gender; Goals; Impaired cognition; Individual; Link; Location; Measures; Memory; Methods; Modeling; Multivariate Analysis; Neurobiology; Neuropsychological Tests; Neuropsychology; Pathology; Process; Public Health; Research; Research Project Summaries; Sex Differences; Stimulus; Time; United States National Institutes of Health; Well in self; Woman; Word Processing; aged; aging population; behavior measurement; cognitive ability; cognitive capacity; cognitive function; cognitive process; demented; emotional functioning; emotional stimulus; executive function; gender difference; human old age (65+); men; mild cognitive impairment; negative affect; neglect; neural; neurophysiology; neuropsychiatry; normal aging; response; temporal measurement; theories; young adult

PROJECT SUMMARY This research addresses concerns in an NIH PAR, “Emotional Function in Normal Aging and/or MCI and AD/ADRD”. It expands on foundational research in order to clarify the trajectories of change in emotional processing and linked neurobiological factors in adults who are aging normally, as well as in individuals with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). Its goals focus on 1) normative maturational shifts in emotional processing, and 2) how dysfunction in the integrative neural-behavioral mechanisms of emotional function manifest in MCI and the early stages of AD/ADRD. We propose to study brain Event- Related Potentials (ERPs) in the context of affective processing of word stimuli based on the classic, quantitative three-dimensional theory of affective (emotional) meaning developed by C.E. Osgood. Can the emotional changes which accompany aging be elucidated by brain ERPs measured during processing of affective word stimuli? What are the relationships among our ERP and behavioral measures and our neuropsychological measures of cognitive ability and neuropsychiatric assessments of affect and emotion? These questions will be studied in young adults, in elderly with normal cognition, and in like-aged individuals afflicted with MCI and early-stage AD. In addition, we will examine how affective meaning in ERPs change in MCI/early-stage AD when compared with like-aged normal elderly. Also studied will be the effects of gender differences on affective meaning ERP measures both in the aging analyses and the cognitive impairment analyses of MCI/AD. Our experimental design builds on a strong, empirically-supported framework of affective processing and emphasizes the affective differences within Osgood’s model. Multivariate analysis methods will be utilized, including separately studying combinations of ERP components related to particular connotative word classes for men and for women.

项目摘要 这项研究解决了NIH PAR中的问题，“正常衰老和/或MCI中的情绪功能， AD/ADRD”。它扩展了基础研究，以澄清情绪变化的轨迹， 处理和相关的神经生物学因素在成年人谁是正常老化，以及在个人与 轻度认知障碍（MCI）和阿尔茨海默病（AD）。它的目标集中在1）规范的成熟 情绪处理的变化，以及2）如何在整合神经行为机制的功能障碍， 情绪功能在MCI和AD/ADRD的早期阶段表现出来。我们建议研究大脑事件- 相关电位（ERPs）在词汇刺激情感加工背景下的经典， 情感意义的三维定量理论。奥斯古德能否 随着年龄的增长，情绪的变化可以通过大脑在处理过程中测量的ERPs来阐明。 情感词汇刺激我们的ERP和行为测量之间的关系是什么？ 认知能力的神经心理学测量和情感和情绪的神经精神病学评估？ 这些问题将在年轻人、认知正常的老年人以及同龄人中进行研究 患有轻度认知障碍和早期AD此外，我们还将研究ERP中的情感意义如何在 MCI/早期AD与同龄正常老年人比较。还将研究性别的影响 年龄分析和认知障碍在情感意义ERP测量上的差异 MCI/AD的分析。我们的实验设计建立在一个强有力的，情感支持的框架上， 处理和强调奥斯古德模型中的情感差异。多变量分析方法 包括分别研究与特定业务有关的企业资源规划组成部分的组合， 男性和女性的内涵词类别。