Brain ERPs to Assess Emotional Function in Normal Aging and MCI/AD

项目总结 这项研究在一项NIH PAR中解决了人们的担忧：正常衰老和/或MCI的情绪功能 AD/ADRD“。它扩展了基础研究，以澄清情绪变化的轨迹 正常衰老的成年人以及患有老年病的个体的加工和相关神经生物学因素 轻度认知障碍(MCI)和阿尔茨海默病(AD)。它的目标集中在1)规范性成熟 情绪处理的转变，以及2)整合神经-行为机制的功能障碍 情绪功能在MCI和AD/ADRD的早期表现。我们计划研究大脑事件-- 相关电位(ERPs)在基于经典的词刺激的情感处理的上下文中， C.E.奥斯古德发展的情感(情感)意义的定量三维理论。能不能 随着年龄增长的情绪变化可以通过脑内事件相关电位的测量来阐明。 情绪化的词语刺激？我们的ERP和行为测量与我们的 认知能力的神经心理学测量以及对情感和情绪的神经精神评估？ 这些问题将在年轻人、认知正常的老年人和同龄个体中进行研究。 患有MCI和早期阿尔茨海默病。此外，我们还将考察事件相关电位中情感意义的变化。 MCI/早期AD与同龄正常老年人比较。此外，还将研究性别的影响 认知障碍与增龄分析中情感意义事件相关电位测量的差异 MCI/AD分析。我们的实验设计建立在一个强大的、有经验支持的情感框架之上 并强调了奥斯古德模型中的情感差异。多元分析方法 将被利用，包括单独研究与特定项目有关的企业资源规划组成部分的组合 专为男性和女性而设的内涵词类。

PROJECT SUMMARY This research addresses concerns in an NIH PAR, “Emotional Function in Normal Aging and/or MCI and AD/ADRD”. It expands on foundational research in order to clarify the trajectories of change in emotional processing and linked neurobiological factors in adults who are aging normally, as well as in individuals with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). Its goals focus on 1) normative maturational shifts in emotional processing, and 2) how dysfunction in the integrative neural-behavioral mechanisms of emotional function manifest in MCI and the early stages of AD/ADRD. We propose to study brain Event- Related Potentials (ERPs) in the context of affective processing of word stimuli based on the classic, quantitative three-dimensional theory of affective (emotional) meaning developed by C.E. Osgood. Can the emotional changes which accompany aging be elucidated by brain ERPs measured during processing of affective word stimuli? What are the relationships among our ERP and behavioral measures and our neuropsychological measures of cognitive ability and neuropsychiatric assessments of affect and emotion? These questions will be studied in young adults, in elderly with normal cognition, and in like-aged individuals afflicted with MCI and early-stage AD. In addition, we will examine how affective meaning in ERPs change in MCI/early-stage AD when compared with like-aged normal elderly. Also studied will be the effects of gender differences on affective meaning ERP measures both in the aging analyses and the cognitive impairment analyses of MCI/AD. Our experimental design builds on a strong, empirically-supported framework of affective processing and emphasizes the affective differences within Osgood’s model. Multivariate analysis methods will be utilized, including separately studying combinations of ERP components related to particular connotative word classes for men and for women.