Resveratrol & Natur Polyphenols: Mech of Proteolitic Clear of AB/Marambaud, Phil

白藜芦醇

• 批准号: 7439866
• 负责人: Giulio Maria Pasinetti
• 金额: $ 15.23万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7439866
• 关键词: Aging; Alzheimer' s Disease; Amyloid; Animal Model; Antioxidants; Appendix; Binding; Biodistribution; Biological; Biological Availability; Brain; Cell Culture System; Cognitive; Complementary and alternative medicine; Consumption; Cultured Cells; Data; Deposition; Deterioration; Disease; Endopeptidases; Epidemiologic Studies; Glucuronides; Goals; In Vitro; Inorganic Sulfates; Liquid Chromatography; Mediating; Methods; Modeling; Molecular; Nerve Degeneration; Organism; Patients; Peptide Hydrolases; Peptides; Peripheral; Plasmin; Prevention; Process; Property; Resveratrol; Risk; Rodent; Rodent Model; Role; Safety; Stress; Testing; Tg2576; Tissues; Transgenic Mice; Unspecified or Sulfate Ion Sulfates; Wine; accelerator mass spectrometry; glucuronide; improved; in vivo; medical schools; mouse model; novel; polyphenol; response

Concordant epidemiological studies have demonstrated that moderate consumption of wine reduces the risk of developing Alzheimer's disease. Several antioxidant polyphenols occur in abundance in wine and are suspected to contribute to the beneficial effect of wine consumption in Alzheimer's disease. Despite skepticism concerning the bioavailability of these polyphenols, recent in vivo data have clearly demonstrated the neuroprotective properties of the naturally occurring polyphenol resveratrol in rodent models for stress and diseases, and consequently, a safety-efficacy study in Alzheimer's disease patients treated with resveratrol is currently conducted at the Mount Sinai School of Medicine. However, the exact molecular mechanisms involved in the beneficial properties of resveratrol and other natural polyphenols on the neurodegenerative process in Alzheimer's disease brain, remain to be clearly defined. Our recent data have revealed that resveratrol (frans-3,4',5-trihydroxystilbene) markedly lowers the levels of amyloid-p peptides in cell culture systems (see appendix 1). The long-term goal of this application is to elucidate the bioavailability of resveratrol and its metabolites in rodents and to characterize their anti-amyloidogenic properties in vitro and in vivo as a necessary prerequisite to the identification of novel complementary and alternative medicines for the prevention of the neurodegenerative mechanisms associated with Alzheimer's disease.

一致的流行病学研究表明，适度饮用葡萄酒可以降低风险