Small Animal Laboratory Core
小动物实验室核心
基本信息
- 批准号:7477133
- 负责人:
- 金额:$ 33.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:All SitesAnatomyAnimal Cancer ModelAnimal ExperimentsAnimal ModelAnimalsArchivesAreaArtsBiodistributionBiological AssayBloodBone DiseasesCardiacCell LineCellsClinicalCollectionCost SavingsCulture TechniquesCultured CellsCultured Tumor CellsDailyDataData AnalysesData ElementDevelopmentDiagnosticDiagnostic radiologic examinationDiseaseDoctor of PhilosophyDoseEnd PointEnsureEquipmentEquipment and supply inventoriesEvaluationExperimental DesignsFreezingFunctional ImagingFundingGoldGrantGreen Fluorescent ProteinsGrowthHeart NeoplasmsHistologyImageImage AnalysisImaging TechniquesImaging technologyIndividualInjection of therapeutic agentIntramuscularKnowledgeLaboratoriesLaboratory AnimalsLesionLifeLongevityMaintenanceMalignant NeoplasmsMeasurementMeasuresMetastatic Neoplasm to the BoneMethodsModelingMolecularMonitorMultiple MyelomaNeoplasm MetastasisOperative Surgical ProceduresOsteolysisOsteolyticPatientsPhysiologicalPositron-Emission TomographyPre-Clinical ModelPrincipal InvestigatorProceduresProgram Research Project GrantsProtocols documentationQuality ControlRadiationRangeReagentResearch PersonnelResearch Project GrantsResolutionResourcesRodentRoleRouteSample SizeScienceSecondary toServicesSiteSkeletal systemSkeletonSolutionsSpecimenStandards of Weights and MeasuresTailTechnetium Tc 99m MedronateTechnical ExpertiseTechniquesTestingTherapeutic AgentsTimeTissuesTumor BurdenTumor Cell InvasionTumor Cell LineUse of New TechniquesValidationVeinsWorkX-Ray Computed Tomographybasebonebone qualitycell growthcell preparationexperiencefluorescence imagingin vivo Modelinterestmalignant breast neoplasmmouse modelneoplastic cellnewsnovel strategiesoptical imagingpre-clinicalprogramsresearch studyresponsesingle photon emission computed tomographyskillssoft tissuestatistical servicesubcutaneoustime usetissue culturetumortumor growth
项目摘要
The theme of this Program Project Grant is heavily based around the use of preclinical in vivo
models to study the molecular mechanisms involved with the effects to cancer on the skeleton.
Each project requires the use of animal models and careful assessment and monitoring of those
animals for both skeletal and soft tissue metastases. The Small Animal Core proposed here will
provide support for all work involving animals within each individual project. Services will include
maintenance of tumor cell lines, management of all procedures involving small animals as well as
state-of-the art methods for assessing the effects of cancer on the skeleton. This core builds on the
previously existing laboratory core by incorporating new techniques such as optical imaging of
green fluorescent protein expressing tumor cells, MicroSPECT, MicroPET and microCT for the
assessment of tumor effects of the skeleton and tumor burden. An additional strength of the Small
Animal Core is the participation of recognized experts in these areas. Techniques such as
MicroSPECT, Micro PET and MicroCT are used in clinical diagnostics for patients with both breast
cancer and multiple myeloma but to our knowledge have not yet been utilized in small animal
models of metastatic disease. Use of these techniques will allow us to make direct comparisons
between our preclinical models and disease in patients providing for validation of our preclinical
models of breast cancer and multiple myeloma. Furthermore, these techniques will build on those
that we have used in the past such as radiography and histomorphometry by allowing us to obtain a
much more thorough picture of tumor burden and distribution in the whole intact animal, while
providing much better resolution.
这个项目的主题是以活体临床前应用为基础的
研究癌症对骨骼影响的分子机制的模型。
每个项目都需要使用动物模型,并对其进行仔细的评估和监测
用于骨骼和软组织转移的动物。这里提出的小动物核心将
为每个单独项目中涉及动物的所有工作提供支持。服务将包括
维持肿瘤细胞系,管理所有涉及小动物的程序以及
评估癌症对骨骼影响的最新方法。这一核心构建在
通过采用光学成像等新技术,实现了以前存在的实验室岩心
表达绿色荧光蛋白的肿瘤细胞、microSPECT、microPET和microCT
评估肿瘤对骨骼和肿瘤负担的影响。小的一个额外的力量
动物核心是这些领域公认的专家的参与。技术,如
MicroSPECT、Micro PET和MicroCT在双侧乳腺临床诊断中的应用
癌症和多发性骨髓瘤,但据我们所知,还没有在小动物身上使用
转移性疾病的模型。使用这些技术将使我们能够进行直接比较
我们的临床前模型和患者的疾病之间的关系,为我们的临床前模型提供了验证
乳腺癌和多发性骨髓瘤的模型。此外,这些技术将建立在这些基础上
我们在过去使用的,如放射摄影术和组织形态计量学,通过允许我们获得
更全面的肿瘤负荷和在整个完整动物中的分布情况,而
提供更好的分辨率。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BRIAN A. HERMAN其他文献
BRIAN A. HERMAN的其他文献
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{{ truncateString('BRIAN A. HERMAN', 18)}}的其他基金
ROLE OF CASPASE-2 IN OSTEOCOLAST APOPTOSIS AGE-EePENDENT OSTEOPOROSIS
CASPASE-2 在破骨细胞凋亡中的作用年龄相关性骨质疏松症
- 批准号:
7233105 - 财政年份:2006
- 资助金额:
$ 33.65万 - 项目类别:
The Mitochondrial Permeabilty Transition in Apoptosis
细胞凋亡中的线粒体通透性转变
- 批准号:
6763185 - 财政年份:2001
- 资助金额:
$ 33.65万 - 项目类别:
The Mitochondrial Permeabilty Transition in Apoptosis
细胞凋亡中的线粒体通透性转变
- 批准号:
6607261 - 财政年份:2001
- 资助金额:
$ 33.65万 - 项目类别:
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