Giving prostate cancer enough rope with bipolar androgen therapy

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For almost 80 years, the main way to treat advanced prostate cancer has been to cut off the supply of male hormones. Unfortunately, this is only temporarily effective and compromises patients’ quality of life. New clinical trials show that the reverse approach – over-supplying hormones to the tumour – is effective and improves quality of life. This project will use novel models of prostate cancer to identify which patients will get the most benefit from this new treatment strategy.