Cell Therapy for Improving Cardiac Function
改善心脏功能的细胞疗法
基本信息
- 批准号:7212901
- 负责人:
- 金额:$ 55.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-01-01 至 2011-12-31
- 项目状态:已结题
- 来源:
- 关键词:Acute myocardial infarctionAddressAdenosineAdmission activityAftercareAgeBedsBlood VesselsBone MarrowBone Marrow CellsCardiacCardiomyopathiesCathetersCell AdhesionCell TherapyCell-Matrix JunctionCellsCessation of lifeChronicClinicalClinical InvestigatorClinical ProtocolsClinical ResearchClinical Research ProtocolsCongestive Heart FailureConsentCoronaryCoronary Artery BypassCoronary CirculationCoronary heart diseaseCoronary sinus structureDevelopmentDiagnosisDilated CardiomyopathyDiseaseEFRACEngraftmentEnrollmentExperimental ModelsFicollFosteringFutureHarvestHealedHeartHeart DiseasesHeart TransplantationHeart failureHomingHospitalizationHospitalsInfarctionInfusion proceduresLeft Ventricular DysfunctionLeft Ventricular Ejection FractionLeft Ventricular FunctionMagnetic Resonance ImagingMediatingMedicalMedicareMesenchymalMesenchymal Stem CellsMononuclearMuscle CellsMyocardialMyocardial InfarctionMyocardiumNatural regenerationNumbersOperative Surgical ProceduresOrganPatientsPlacebosPopulationPreparationPreventionProceduresProcessPropertyRandomizedReportingResearchResearch PersonnelResidual stateRoleSkeletal systemStagingStandards of Weights and MeasuresStem cellsStructureTestingTimeTissuesTrainingTreatment EfficacyUnited StatesUpper armVentricular FunctionViralWeekWorkWound Healingabstractingangiogenesiscell preparationcell typecytokinedaydesignexperiencehealingheart functionimprovedindexingparacrineplacebo controlled studypreventprogramsprospectiveskills
项目摘要
DESCRIPTION (provided by applicant):
Heart Failure is the most common reason for admission to hospitals in the United States, especially in the Medicare population. A majority of patients with HF have poor left ventricular function, with 60-70% due to chronic ischemic coronary disease. The remainder of patients experience HF due to a variety of other causes, including idiopathic and viral cardiomyopathies, and are classified as dilated non-ischemic cardiomyopathies.
Stem cells (endothelial, mesenchymal, skeletal or from bone marrow), injected directly into the myocardium or delivered to the coronary circulation, can improve cardiac function in chronic ischemic cardiomyopathy or following an acute myocardial infarction. While there is evidence that cell therapy can improve cardiac function, the exact mechanisms through which cell therapy exerts beneficial effects remain unclear. We and others have demonstrated that the cardioprotective effects of endothelial progenitor cells (EPCs) following myocardial infarction are mediated, in part, by multiple cytokines secreted by stem cells, which can favorably enhance myocardial survival. We postulate that an enriched, mixed, stem cell population may offer an advantage over a single cell type. It is also evident from our studies that active interaction between stem cells and the vascular wall during systemic delivery is necessary for efficient grafting to occur.
This proposal describes two clinical protocols to use bone marrow-derived cells for the treatment of left ventricular dysfunction. The first will test the hypothesis that expansion of bone marrow cells to yield high levels of endothelial and mesenchymal progenitor cells will produce a greater improvement in cardiac function compared to freshly harvested bone marrow cells. The second will investigate the role of cell therapy in dilated non-ischemic cardiomyopathy and test the hypothesis that adenosine pretreatment will enhance cell homing potentiating the beneficial effects of cell therapy. To foster future research, a Clinical Research Skills Development Core will train new clinical investigators in cardiac cell-therapy.
The two clinical protocols will determine the efficacy of different cell preparations and the role of modulating stem cell engraftment in target tissue to restore ventricular function opening the way for feasible, easily applied strategies to capture the healing properties of bone marrow-derived cells. (End of Abstract)
描述(由申请人提供):
Heart Failure is the most common reason for admission to hospitals in the United States, especially in the Medicare population.大多数心力衰竭患者左心室功能较差,其中60-70%是由于慢性缺血性冠状动脉疾病所致。其余患者因各种其他原因(包括特发性和病毒性心肌病)而出现心力衰竭,并被归类为扩张型非缺血性心肌病。
Stem cells (endothelial, mesenchymal, skeletal or from bone marrow), injected directly into the myocardium or delivered to the coronary circulation, can improve cardiac function in chronic ischemic cardiomyopathy or following an acute myocardial infarction.虽然有证据表明细胞疗法可以改善心脏功能,但细胞疗法发挥有益作用的确切机制仍不清楚。我们和其他人已经证明,心肌梗死后内皮祖细胞(EPC)的心脏保护作用部分是由干细胞分泌的多种细胞因子介导的,这可以有利地提高心肌存活率。我们假设富集的混合干细胞群可能比单一细胞类型具有优势。从我们的研究中还可以明显看出,在全身输送过程中干细胞和血管壁之间的积极相互作用对于有效移植的发生是必要的。
该提案描述了使用骨髓来源细胞治疗左心室功能障碍的两种临床方案。第一个将检验这样的假设:与新鲜收获的骨髓细胞相比,扩增骨髓细胞以产生高水平的内皮和间充质祖细胞将产生更大的心脏功能改善。第二部分将研究细胞疗法在扩张型非缺血性心肌病中的作用,并检验腺苷预处理将增强细胞归巢从而增强细胞疗法的有益效果的假设。为了促进未来的研究,临床研究技能发展核心将培训心脏细胞治疗方面的新临床研究人员。
这两个临床方案将确定不同细胞制剂的功效以及调节干细胞在靶组织中植入以恢复心室功能的作用,为可行、易于应用的策略来捕获骨髓来源细胞的愈合特性开辟了道路。 (摘要完)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Douglas E Vaughan其他文献
1007-182 Aldosterone and plasma renin activity influence plasma plasminogen activato inhibitor-1 levels in overweight subjects
- DOI:
10.1016/s0735-1097(04)91875-x - 发表时间:
2004-03-03 - 期刊:
- 影响因子:
- 作者:
James A.S Muldowney;Barbara C Roberts;Joseph W Covington;John A Schoenhard;Nancy J Brown;Douglas E Vaughan - 通讯作者:
Douglas E Vaughan
1064-181 Distinct signaling pathways mediate protease activated receptor-dependent endothelial exocytosis
- DOI:
10.1016/s0735-1097(04)91968-7 - 发表时间:
2004-03-03 - 期刊:
- 影响因子:
- 作者:
John H Cleator;Douglas E Vaughan;Heidi E Hamm - 通讯作者:
Heidi E Hamm
Douglas E Vaughan的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Douglas E Vaughan', 18)}}的其他基金
Evolutionary Advantage of Heterozygous PAI-1 Deficiency in Humans
人类杂合 PAI-1 缺陷的进化优势
- 批准号:
10686583 - 财政年份:2022
- 资助金额:
$ 55.41万 - 项目类别:
Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
PAI-1 缺陷小鼠和男性的自发性心脏纤维化:一种罕见的突变揭示了一种常见的分子病理生理学
- 批准号:
10402774 - 财政年份:2019
- 资助金额:
$ 55.41万 - 项目类别:
Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
PAI-1 缺陷小鼠和男性的自发性心脏纤维化:一种罕见的突变揭示了一种常见的分子病理生理学
- 批准号:
9908161 - 财政年份:2019
- 资助金额:
$ 55.41万 - 项目类别:
DEFINING STRATEGIES FOR IMPROVING ENDOTHELIAL/FIBRINOLYTIC DYFUNCTION IN OBESITY
制定改善肥胖症内皮/纤溶功能障碍的策略
- 批准号:
7605664 - 财政年份:2006
- 资助金额:
$ 55.41万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 55.41万 - 项目类别:
Research Grant