Heart Failure Clinical Research Network - RCC

描述(由申请人提供)： 心力衰竭(HF)是西方世界最常见的疾病之一，是导致 相当高的发病率和死亡率。尽管近几十年来，心力衰竭的治疗方法有所改善，但许多重要的临床问题仍未得到解决。现有的临床试验主要集中于非卧床患者的慢性心力衰竭，而心力衰竭综合征的其他组成部分，如急性心力衰竭、晚期心力衰竭和收缩功能保留的心力衰竭，研究较少，了解也很少。此外，在年龄、性别、种族和民族方面，临床试验患者的人口统计学特征通常与更广泛的心力衰竭人群有很大不同。多中心协作临床研究的现有基础设施缺乏，包括学术和社区站点，这导致缺乏可推广的科学进步。心力衰竭临床研究网络旨在创建一个由经验丰富的专门研究团队组成的全国性网络，以解决心力衰竭中尚未回答的关键问题。 杜克大学医学中心的心力衰竭项目在临床护理、研究和教学方面有着悠久的卓越历史。特别是，我们在协作、高质量、科学严谨的临床研究方面有着良好的记录。我们与整个地区的学术中心和社区实践都有长期的合作关系。我们相信，我们的专业知识和经验与这个庞大的地区转介网络相结合，将使我们成为心力衰竭临床试验网络的一个有价值的地区临床中心(RCC)。在这项建议中，我们有以下具体目标： 1)与其他RCC和数据协调中心(DCC)合作，开展高质量的多中心研究，解决高频领域尚未回答的重要问题。 2)开发创新的、科学严谨的临床方案，供网络审议，重点关注心力衰竭领域与临床相关的未解答问题 3)利用现有的本地和地区转诊网络，最大限度地提高社区站点对临床方案的参与，并将数据传播到更广泛的临床社区 4)创建临床研究技能开发核心，以培养下一代临床研究人员，在心力衰竭领域进行科学严谨、影响深远的临床研究 为了实现这些目标，我们组建了一支经验丰富、敬业的调查团队以及学术和社区合作伙伴。这些目标的成功实现将对心力衰竭网络和心力衰竭患者的整体护理做出重大贡献。(摘要结束)

DESCRIPTION (provided by applicant): Heart failure (HF) is among the most common diseases in the western world and is responsible for Substantial morbidity and mortality. Although recent decades have seen improvements in therapy for HF, many important clinical questions remain unaddressed. Existing clinical trials have primarily focused on chronic HF in ambulatory patients, while a variety of other components of the HF syndrome, such as acute HF, advanced stage D HF, and HF with preserved systolic function, remain little studied and poorly understood. Additionally, the demographics of clinical trial patients often differ substantially from the broader heart failure population with regard to age, gender, race, and ethnicity. Existing infrastructure for multicenter, collaborative clinical research incorporating both academic and community sites is lacking, contributing to the lack of generalizable scientific progress. The Heart Failure Clinical Research Network is designed to create a national network of experienced, dedicated research teams to address critical unanswered questions in HF. The Heart Failure program at Duke University Medical Center has a long history of excellence in clinical care, research, and teaching. In particular, we have a track record of collaborative, high-quality, scientifically rigorous clinical research. We have long standing collaborative relationships with both academic centers and community practices throughout the region. We believe the combination of our expertise and experience with this substantial regional referral network would make us a valuable Regional Clinical Center (RCC) of the Heart Failure Clinical Trials Network. In this proposal, we have the following specific aims: 1) To collaborate with other RCCs and the Data Coordinating Center (DCC) in performing high quality, multi-center research addressing important unanswered questions in the field of HF. 2) To develop innovative, scientifically rigorous clinical protocols for consideration by the network, focused on clinically relevant unanswered questions in the field of HF 3) To leverage existing local and regional referral networks to maximize the participation of community sites in clinical protocols, and the dissemination of data into the broader clinical community 4) To create a Clinical Research Skills Development Core in order to train the next generation of clinical investigators to perform scientifically rigorous, high impact clinical research in the field of HF To accomplish these goals, we have assembled an experienced, dedicated team of investigators and academic and community partners. The successful accomplishment of these aims will be a significant contribution to both the Heart Failure Network and the overall care of patients with heart failure. (End of Abstract)