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Heart Failure Clinical Research Network - RCC

心力衰竭临床研究网络 - RCC

基本信息

批准号：
7475104
负责人：
CHRISTOPHER M O'CONNOR
金额：
$ 50.49万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-30 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7475104
关键词：
Academic Medical Centers Acute Address Adverse event Age Ancillary Study Award Basic Science Biometry Caring Chronic Clinical Clinical Investigator Clinical Protocols Clinical Research Clinical Trials Clinical Trials Data Monitoring Committees Clinical Trials Design Clinical Trials Network Collaborations Commit Communities Community Participation Community Physician Community Practice Condition Dancing Data Data Collection Data Coordinating Center Development Diastolic heart failure Disease Educational process of instructing Enrollment Ensure Epidemiology Ethnic Origin Gender Genomics Goals Grant Heart failure Institution Knowledge Master&apos s Degree Measures Medical Methods Mitral Valve Morbidity - disease rate Numbers Other Resources Outcome Participant Patient Care Patient Recruitments Patient Selection Patients Physicians Policies Population Preparation Procedures Protocols documentation Publications Race Rate Recording of previous events Recruitment Activity Reporting Research Research Design Research Infrastructure Research Personnel Review Committee Site Site Visit Staging Standards of Weights and Measures Statistical Methods Support of Research Syndrome Telephone Testing Therapeutic Intervention Therapy Evaluation Time TimeLine Training Training Programs U-Series Cooperative Agreements Voting Western World Work Writing abstracting base clinically relevant cost effectiveness demographics design effectiveness research experience follow-up health economics human subject improved innovation mortality next generation novel programs protocol development quality assurance racial and ethnic repaired research and development skills success symposium

项目摘要

DESCRIPTION (provided by applicant): Heart failure (HF) is among the most common diseases in the western world and is responsible for Substantial morbidity and mortality. Although recent decades have seen improvements in therapy for HF, many important clinical questions remain unaddressed. Existing clinical trials have primarily focused on chronic HF in ambulatory patients, while a variety of other components of the HF syndrome, such as acute HF, advanced stage D HF, and HF with preserved systolic function, remain little studied and poorly understood. Additionally, the demographics of clinical trial patients often differ substantially from the broader heart failure population with regard to age, gender, race, and ethnicity. Existing infrastructure for multicenter, collaborative clinical research incorporating both academic and community sites is lacking, contributing to the lack of generalizable scientific progress. The Heart Failure Clinical Research Network is designed to create a national network of experienced, dedicated research teams to address critical unanswered questions in HF. The Heart Failure program at Duke University Medical Center has a long history of excellence in clinical care, research, and teaching. In particular, we have a track record of collaborative, high-quality, scientifically rigorous clinical research. We have long standing collaborative relationships with both academic centers and community practices throughout the region. We believe the combination of our expertise and experience with this substantial regional referral network would make us a valuable Regional Clinical Center (RCC) of the Heart Failure Clinical Trials Network. In this proposal, we have the following specific aims: 1) To collaborate with other RCCs and the Data Coordinating Center (DCC) in performing high quality, multi-center research addressing important unanswered questions in the field of HF. 2) To develop innovative, scientifically rigorous clinical protocols for consideration by the network, focused on clinically relevant unanswered questions in the field of HF 3) To leverage existing local and regional referral networks to maximize the participation of community sites in clinical protocols, and the dissemination of data into the broader clinical community 4) To create a Clinical Research Skills Development Core in order to train the next generation of clinical investigators to perform scientifically rigorous, high impact clinical research in the field of HF To accomplish these goals, we have assembled an experienced, dedicated team of investigators and academic and community partners. The successful accomplishment of these aims will be a significant contribution to both the Heart Failure Network and the overall care of patients with heart failure. (End of Abstract)

描述（由申请人提供）：心力衰竭（HF）是西方世界最常见的疾病之一，发病率和死亡率很高。尽管近几十年来HF治疗有所改善，但许多重要的临床问题仍未解决。现有的临床试验主要集中在非卧床患者的慢性HF，而HF综合征的各种其他组成部分，如急性HF，晚期D HF和保留收缩功能的HF，仍然很少研究和了解甚少。此外，临床试验患者的人口统计学特征通常与更广泛的心力衰竭人群在年龄、性别、人种和种族方面存在显著差异。现有的基础设施，多中心，合作临床研究，包括学术和社区网站是缺乏的，导致缺乏普遍的科学进步。心力衰竭临床研究网络旨在创建一个由经验丰富、专业的研究团队组成的全国网络，以解决心力衰竭中悬而未决的关键问题。杜克大学医学中心的心力衰竭项目在临床护理、研究和教学方面有着悠久的历史。特别是，我们有协作，高质量，科学严谨的临床研究的跟踪记录。我们与整个地区的学术中心和社区实践都有长期的合作关系。我们相信，我们的专业知识和经验与这个庞大的区域转诊网络相结合，将使我们成为心力衰竭临床试验网络的一个有价值的区域临床中心（RCC）。在这项建议中，我们有以下具体目标： 1)与其他RCC和数据协调中心（DCC）合作，开展高质量的多中心研究，解决HF领域尚未解决的重要问题。 2)制定创新的、科学严谨的临床方案供网络考虑，重点关注HF领域临床相关的未回答问题 3)利用现有的本地和区域转诊网络，最大限度地提高社区研究中心对临床方案的参与度，并将数据传播到更广泛的临床社区 4)创建临床研究技能开发核心，以培训下一代临床研究者在HF领域进行科学严谨、高影响力的临床研究为了实现这些目标，我们组建了一支经验丰富、敬业的调查人员、学术和社区合作伙伴团队。这些目标的成功实现将对心力衰竭网络和心力衰竭患者的整体护理做出重大贡献。(End摘要）