WEIGHT LOSS MAINTENANCE TRIAL

减肥维持试验

• 批准号: 7162638
• 负责人: JACK F HOLLIS
• 金额: $ 19.56万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-15 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162638
• 关键词: African American; Arts; Behavior Therapy; Body Weight Changes; Body Weight decreased; Cardiovascular system; Caring; Cause of Death; Communication; Complement; Control Groups; Dyslipidemias; Epidemic; Exercise stress test; Healthcare Systems; Hypertension; Individual; Intervention; Maintenance; Measures; Non-Insulin-Dependent Diabetes Mellitus; Numbers; Obesity; Online Systems; Outcome; Overweight; Participant; Pharmaceutical Preparations; Physical activity; Prevalence; Procedures; Purpose; Randomized; Randomized Controlled Trials; Rate; Risk; Risk Factors; Subgroup; Technology; Telephone; Testing; Training; Weight; Weight maintenance regimen; Woman; behavior change; cost; design; innovation; prevent; programs; stem; success; weight maintenance

Overweight/obesity is the second leading cause of death in the US, and is growing in prevalence at an alarming rate. Control of overweight/obesity is increasingly recognized as a high national priority because of its contribution to cardiovascular (CVD) risk factors and ultimately to CVD itself. The short-term success of behavioral interventions for weight loss has been repeatedly documented. Unfortunately, because weight re-gain is extremely common, a disappointingly small proportion of individuals achieve long-term weight control. Of the factors that are associated with sustained weight loss, one of the most important is continued intervention with frequent contacts. We propose a multi- center, randomized, controlled trial [Weight Loss Maintenance Trial (MAINTENANCE)] to determine the effects of two innovative behavioral interventions, each designed to maintain frequent contacts, compared to a usual care control group. Overweight and obese individuals (~60% women, -40% African Americans) who are taking medication for hypertension, dyslipidemia and/or type 2 diabetes will enter a 6 month weight loss program. Those individuals who lose at least 4 kg (N = 800) will then be randomized into one of three groups: a Personal Contact (PC) Intervention that provides monthly personal contacts with a trained interventionist, primarily via telephone; an Interactive Technology (IT) Intervention that provides frequent contacts through a state-of-the-art interactive web-based program supplemented by other communication technologies; or Usual Care (UC). The primary outcome will be weight change from the end of the initial weight loss program to the end of the 30-month weight maintenance intervention period. Other outcomes will include weight change in subgroups, prevalence of CVD risk factors, measures of behavior change, and cost of implementation. For each outcome, the PC and IT interventions will be compared to UC, and if different from UC, to each other. To successfully combat the obesity epidemic, clinicians and health care systems must have options that are effective and feasible, and that can be provided to large numbers of individuals. The purpose of this proposal is to develop and test two such interventions, which, if effective, should complement ongoing efforts to stem the obesity epidemic and ultimately prevent obesity-related CVD.

超重/肥胖是美国第二大死亡原因，并且患病率正在以惊人的速度增长。 控制超重/肥胖越来越被认为是国家的高度优先事项，因为它有助于 心血管 (CVD) 危险因素并最终影响 CVD 本身。行为干预的短期成功 减肥已被多次记录。不幸的是，由于体重重新增加极为常见， 令人失望的是，只有一小部分人实现了长期体重控制。与以下因素相关的 持续的减肥，最重要的之一是经常接触的持续干预。我们提出了一个多 中心、随机、对照试验 [减肥维持试验 (MAINTENANCE)] 以确定的效果 与常规护理控制相比，两种创新的行为干预措施均旨在保持频繁接触 团体。正在服用药物治疗的超重和肥胖个体（~60% 女性，-40% 非裔美国人） 高血压、血脂异常和/或2型糖尿病将进入为期6个月的减肥计划。那些失去的人 至少 4 公斤（N = 800）将被随机分为三组之一： 个人接触 (PC) 干预， 每月主要通过电话与训练有素的干预专家进行个人联系；互动技术 (IT) 通过最先进的交互式网络程序提供频繁联系的干预 通过其他通信技术；或常规护理 (UC)。主要结果是最终的体重变化 从最初的减肥计划到30个月的体重维持干预期结束。其他结果 将包括亚组的体重变化、CVD 危险因素的患病率、行为改变的衡量标准以及治疗成本 执行。对于每个结果，PC 和 IT 干预措施将与 UC 进行比较，如果与 UC 不同，则 彼此。为了成功地对抗肥胖流行病，临床医生和医疗保健系统必须有以下选择： 有效且可行，并且可以提供给大量个人。该提案的目的是 开发并测试两种此类干预措施，如果有效，将补充正在进行的遏制肥胖的努力 流行病并最终预防与肥胖相关的心血管疾病。