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中文摘要
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描述(由申请人提供):贝勒医学院乳腺护理中心是一个基础广泛的多学科组织,由致力于探索乳腺癌生物学的研究人员组成,并通过更好地了解这一生物学,提高治愈率和治疗方法。该中心的优势将补充、加强和扩展NSABP的目标。在过去的五年中,我们在贝勒医学院建立了临床存在和基础设施,促进了各种患者的招募到治疗研究中。除了与卫理公会医院合作建立的乳腺护理中心外,我们还成功地在本陶布综合医院建立了一个专门的乳腺肿瘤诊所,这是一家县医院,为大量患有乳腺癌的弱势和少数民族妇女提供服务,并成功地从这一人群中招募人员。在过去的25年里,中心的研究人员在预后和治疗反应预测的分子标记方面积累了相当多的专业知识,最近又将他们的努力扩展到高通量基因组技术。通过繁忙,高容量的临床服务和已建立的临床试验基础设施的综合力量,以及在转化和分子标记研究方面经验丰富的科学家和临床医生,我们将能够为NSABP的目标做出独特的贡献,为所有患有乳腺癌的女性提供最佳的个性化治疗。
英文摘要
DESCRIPTION (provided by applicant): The Breast Care Center at Baylor College of Medicine is a broad based, multidisciplinary organization composed of investigators dedicated to exploring the biology of breast cancer, and through a better understanding of this biology, to improving cure rates and treatments for the disease. The strengths of the Center will complement, reinforce, and extend the goals of the NSABP. Over the past five years, we have established a clinical presence and infrastructure at Baylor College of Medicine which facilitates the recruitment of a wide variety of patients onto treatment studies. Along with our Breast Care Center, established in collaboration with The Methodist Hospital, we have also been successful in establishing a dedicated breast oncology clinic at Ben Taub General Hospital, a county hospital which serves a large number of disadvantaged and minority women with breast cancer, and are successfully recruiting from this population. Center investigators have developed a considerable expertise over the past twenty-five years in molecular markers of prognosis and prediction of response to therapy, and most recently have extended their efforts into high through-put genomic technologies. Through the combined strength of a busy, high volume clinical service and established clinical trial infrastructure, along with scientists and clinicians deeply experienced in translational and molecular marker research, we will be able to make a unique contribution towards the NSABP's goal of optimum, individualized treatment for all women with breast cancer.
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