Effect of Schistosoma Co-infection on HIV Immune Responses

据推测，慢性寄生虫合并感染会增加亚慢性感染者发展为艾滋病的速度。 撒哈拉非洲。乌干达就是这样一个国家，艾滋病毒在该国迅速蔓延， 血吸虫病的血清阳性率已有记载。有人提出慢性血吸虫病 mansoni（S. mansoni）感染促进免疫概况，促进艾滋病毒复制和损害免疫系统。 宿主的抗病毒免疫反应。S.曼氏菌合并感染在HIV发病机制中的作用尚不完全 明白血吸虫病以前曾与更严重的临床过程中，慢性 病毒感染和病毒特异性T细胞功能障碍受损。然而，迄今为止没有研究报告 在共同感染个体中HIV特异性免疫反应的变化。我们假设S. 曼氏菌合并感染改变了HIV患者临床结局和抗病毒细胞免疫的决定因素 疾病本研究旨在探讨与S.曼氏混合感染 在乌干达。该项目将优化和建立在现有的研究和实验室基础上 联合临床研究中心（JCRC）的基础设施与乌干达的经验和人才 科学界以及外部专家的合作和援助。拟议的目标建立在 现有报告以及JCRC和美国实验室生成的初步数据。具体来说，我们 目的是：1）在艾滋病毒血清阳性乌干达志愿者的临床队列中进行纵向研究 在坎帕拉的试验中，对S. mansoni合并感染对HIV疾病进展的影响。2)评价 无论是S.曼氏感染会影响宿主产生HIV抗病毒免疫反应的能力。3）至 探讨了S.曼氏菌感染通过增强细胞免疫应答来失调细胞免疫应答， 产生IL-10的T细胞的活性。S.因此，将在以下背景下检查曼氏菌合并感染： 一种实验性免疫调节剂

Chronic parasitic co-infection has been postulated to increase the rate of progression to AIDS in sub- Saharan Africa . Uganda is one such country in which HIV has spread rapidly and where a high seroprevalence of schistosomiasis has been documented. It has been proposed that chronic Schistosoma mansoni (S. mansoni) infection promotes an immune profile that facilitates HIV replication and impairs the host's antiviral immune response. The impact of S. mansoni co-infection in HIV pathogenesis is not yet fully understood. Schistosomiasis has previously been associated with a more severe clinical course in chronic viral infection and with impaired viral-specific T cell dysfunction. However, no study to date has reported changes in the HIV-specific immune responses in co-infected individuals. We hypothesize that the S. mansoni co-infection alters the determinants of clinical outcome and antiviral cellular immunity in HIV disease. This study proposes to examine potential factors implicated in the pathogenesis of S. mansoni coinfection in Uganda. This project will optimize and build on the established research and laboratory infrastructure of the Joint Clinical Research Centre (JCRC) with the experience and talents of the Ugandan scientific community and the collaboration and assistance of external experts. The proposed aims build on existing reports as well as preliminary data generated at the JCRC and the US laboratories. Specifically, our aims are:1)To conduct a longitudinal study in a clinic-based cohort of HIV seropositive Ugandan volunteers in Kampala and evaluate the effect of S. mansoni co-infection on HIV disease progression. 2) To evaluate whether S. mansoni infection affects the host's ability to generate HIV antiviral immune response. 3)To explore the hypothesis that S. mansoni infection dysregulates cellular immune responses by enhancing the activity of IL-10-producing T cells. S. mansoni co-infection will therefore be examined in the context of being an experimental immune modulator.