CTL RESPONSE IN NON-B CLADE HIV1 INFECTION

描述：(改编自申请者的摘要)本研究旨在帮助 在开发一种适合于 感染非B分支病毒的人群，通过定义相关方面 非B分支猪瘟病毒感染中的免疫反应 HIV-1，包括CTL交叉识别的详细检查。 有待探讨的相关问题包括：a)评估CTL的频谱 塞内加尔非B分支感染者特定队列中的反应 病毒，在急性和慢性感染中；b)确定最佳免疫原性 Non-B分支特异性CTL识别的表位和确定 这些表位的HL-限制，c)确定保守程度 或这些CTL与其他分支病毒，即A、B、C、 D和E，以及d)确定HIV-1特异性CTL克隆的能力 从非B分支感染中产生，以抑制由其他 HIV-1病毒分支。 应聘者：应聘者从哈佛大学获得医学博士学位 加州大学旧金山分校于1990年成立，此后完成了 两年半的临床和博士后奖学金 麻省总医院。 赞助商：布鲁斯·沃克博士是哈佛大学医学院副教授 哈佛医学院和合作伙伴艾滋病研究中心主任 (麻省总医院)。 C.环境：研究和培训将在 麻省总医院，与哈佛大学合作 凯斯西储大学公共卫生学院和 乌干达和塞内加尔。 D.培训计划：应聘者将继续在 两年前在沃克博士的实验室做研究员。

DESCRIPTION: (adapted from applicant's abstract) This study aims to assist in the development of an effective vaccine that is appropriate for populations infected with non-B clade viruses, by defining relevant aspects of the immunological responses seen in infections by non-B clade strains of HIV-1, including detailed examination of CTL cross-clade recognition. Relevant issues to be explored include: a) evaluating the spectrum of CTL responses in defined Senegalese cohorts of persons infected with non-B clade viruses, in acute and chronic infection; b) identifying optimal immunogenic epitopes recognized by non-B clade specific CTLs and determining the HLA-restriction of these epitopes, c) determining the degree of conservation or cross-recognition of these CTLs with other clade viruses, namely A, B, C, D and E, and d) determining the ability of HIV-1-specific CTL clones generated from non-B clade infection to inhibit viral replication by other HIV-1 clades. a. Candidate: The candidate received her medical doctorate from the University of California at San Francisco in 1990, and has since completed two and a half years of clinical and post-doctoral fellowship at the Massachusetts General Hospital. b. Sponsor: Dr. Bruce Walker is an Associate Professor of Medicine at Harvard Medical School and Director of the Partners AIDS Research Center (Massachusetts General Hospital). c. Environment: The research and training will be carried out at the Massachusetts General Hospital, with collaborations involving the Harvard School of Public Health, Case Western Reserve University and groups in Uganda and Senegal. d. Training Plan: The candidate will continue research begun during the prior two years as a fellow in Dr. Walker's laboratory.