Glucocorticoid resistance: identifying new anti-inflammatory drug targets

糖皮质激素抵抗：确定新的抗炎药物靶点

• 批准号: nhmrc : 628691
• 负责人: Prof Alastair Stewart
• 金额: $ 30.23万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glucocorticoid-resistance-identifying-drug-targets/83171
• 关键词: Glucocorticoid; resistance; identifying; new; anti

The control of chronic inflammatory diseases such as asthma involve use of drugs related to the steroid hormone cortisol. Up to 40% of patients with more severe disease respond poorly or not at all to these drugs. The remaining non-steroid treatments are only partially effective. Poor disease control is a great health and economic burden. We have identified a molecular mechanism for steroid resistance and propose new studies to identify novel drugs that act to reverse steroid resistance.

慢性炎症性疾病如哮喘的控制涉及使用与类固醇激素皮质醇相关的药物。高达40%的严重疾病患者对这些药物反应不佳或根本没有反应。其余的非类固醇治疗仅部分有效。疾病控制不力是一个巨大的健康和经济负担。我们已经确定了类固醇耐药的分子机制，并提出了新的研究，以确定能够逆转类固醇耐药的新药。