Emergency Brain Monitor with Telemetry

描述（由申请人提供）：这是一项II期延续提案，旨在为大脑提供我们几十年来在急诊科为心脏所做的事情。在我们之前的工作中，我们已经开发并测试了一种紧凑型遥测脑电图系统，该系统允许患者不受束缚并自由移动，同时仍由远程PC监控。我们在Beaumont医院（Troy, Michigan）的急诊科（ED）对20名精神状态改变的患者进行了实时脑电图监测。结果表明，该装置非常实用，易于在该环境中使用，并且不会妨碍急诊科的传统标准护理。同样重要的是，结果显示，20名患者中有7名发生了非惊厥性癫痫发作（NCS）；用传统方法可能完全忽略的异常大脑活动。另外两名患者的矛盾症状也通过我们的技术得到了解决。在本提案中，我们将完成该技术的开发和商业化，以生产专用于急诊室的第一个无线脑电图设备。我们将用新的无线发射器升级设备（以满足最近发布的FCC指南），重新包装审查模块，使其更加坚固可靠，并通过减少脑电图电极的数量来研究更快的连接时间。一项广泛的临床试验将在密歇根州特洛伊市的博蒙特医院急诊科进行。该装置在市场上是需要的，我们希望它能在急诊室和院前环境中率先广泛使用脑电图。一旦记录在个人电脑上，来自急诊科的实时脑电图就可以通过局域网和互联网连接传输给医院内外任何地方的神经科医生。该设备还将嵌入癫痫检测算法，以促进神经学阅读。最后，虽然我们认识到对标准方案的改变存在潜在的阻力，但我们相信，通过将这项技术商业化，甚至在少数急诊中心成功采用，将构成一个非常必要的步骤，使全国的急诊医生和医院管理者相信脑电图作为现有ED方案的重要补充的重要性。

DESCRIPTION (provided by applicant): This is a Phase II continuation proposal that is meant to provide for the brain what we have been doing for the heart for decades in the emergency department. During our prior work, we have developed and tested a compact telemetry EEG system that allows the patient to be untethered and moved about freely while still being monitored by a remote PC. We have conducted real time EEG monitoring in the Emergency Department (ED) at Beaumont Hospitals (Troy, Michigan) on twenty patients with altered mental status. The results show that the device is very practical and easy to use in that environment and does not impede conventional standard of care in the ED. As importantly, the results show that 7 of 20 patients had Non-Convulsive Seizures (NCS); abnormal brain activity that could have been totally missed using traditional procedures. Conflicting symptoms in two more patients were also resolved using our technology. In this proposal, we will finalize development and commercialization of the technology to produce the first wireless EEG device that is dedicated to the emergency room. We will upgrade the device with a new wireless transmitter (to meet recently issued FCC guidelines), repackage the review module to make it more rugged and reliable, and investigate faster hookup time by reducing the number of EEG electrodes. An extensive clinical trial will be conducted at Beaumont hospital emergency department in Troy, Michigan. The proposed device is needed in the market place and we hope will pioneer the wide-use of EEG in emergency rooms and in prehospital settings. Once recorded in the PC, real time EEG from the ED can be transferred via LAN and internet connections to a neurologist anywhere inside or outside the hospital. The device will also have an embedded seizure detection algorithm to facilitate neurological reading. Finally, while we recognize the potential resistance to changes in standard protocols, we believe that by commercializing this technology and with successful adoption even by few emergency centers will constitute a much needed step to convince the emergency doctors and hospital administrators nationwide of the importance of EEG as a critical complement to existing ED protocols.