Emergency Brain Monitor with Telemetry

描述（由申请人提供）：这是一个第二阶段的延续建议，旨在为大脑提供我们几十年来在急诊室为心脏所做的事情。在我们之前的工作中，我们已经开发并测试了一个紧凑的遥测EEG系统，该系统允许患者不受束缚并自由移动，同时仍由远程PC监控。我们在密歇根州特洛伊市博蒙医院的急诊室（艾德）对20名精神状态改变的患者进行了真实的EEG监测。结果表明，该设备非常实用，易于在该环境中使用，并且不会妨碍ED中的常规护理标准。重要的是，结果表明，20名患者中有7名患有非惊厥性癫痫（NCS）;使用传统程序可能完全错过的异常大脑活动。使用我们的技术，另外两名患者的症状也得到了解决。在这项提案中，我们将完成该技术的开发和商业化，以生产第一台专用于急诊室的无线EEG设备。我们将使用新的无线发射器升级设备（以满足最近发布的FCC指南），重新包装审查模块，使其更加坚固可靠，并通过减少EEG电极数量来研究更快的连接时间。一项广泛的临床试验将在密歇根州特洛伊市的博蒙医院急诊科进行。市场上需要这种拟议的设备，我们希望它能成为脑电图在急诊室和院前环境中广泛使用的先驱。一旦记录在PC中，来自艾德的真实的时间EEG可以通过LAN和互联网连接传输到医院内外任何地方的神经科医生。该器械还将具有嵌入式癫痫发作检测算法，以促进神经阅读。最后，虽然我们认识到标准协议的变化的潜在阻力，但我们相信，通过商业化这项技术，即使是少数急救中心的成功采用，也将构成一个急需的步骤，以说服全国的急诊医生和医院管理人员相信EEG作为现有艾德协议的重要补充。

DESCRIPTION (provided by applicant): This is a Phase II continuation proposal that is meant to provide for the brain what we have been doing for the heart for decades in the emergency department. During our prior work, we have developed and tested a compact telemetry EEG system that allows the patient to be untethered and moved about freely while still being monitored by a remote PC. We have conducted real time EEG monitoring in the Emergency Department (ED) at Beaumont Hospitals (Troy, Michigan) on twenty patients with altered mental status. The results show that the device is very practical and easy to use in that environment and does not impede conventional standard of care in the ED. As importantly, the results show that 7 of 20 patients had Non-Convulsive Seizures (NCS); abnormal brain activity that could have been totally missed using traditional procedures. Conflicting symptoms in two more patients were also resolved using our technology. In this proposal, we will finalize development and commercialization of the technology to produce the first wireless EEG device that is dedicated to the emergency room. We will upgrade the device with a new wireless transmitter (to meet recently issued FCC guidelines), repackage the review module to make it more rugged and reliable, and investigate faster hookup time by reducing the number of EEG electrodes. An extensive clinical trial will be conducted at Beaumont hospital emergency department in Troy, Michigan. The proposed device is needed in the market place and we hope will pioneer the wide-use of EEG in emergency rooms and in prehospital settings. Once recorded in the PC, real time EEG from the ED can be transferred via LAN and internet connections to a neurologist anywhere inside or outside the hospital. The device will also have an embedded seizure detection algorithm to facilitate neurological reading. Finally, while we recognize the potential resistance to changes in standard protocols, we believe that by commercializing this technology and with successful adoption even by few emergency centers will constitute a much needed step to convince the emergency doctors and hospital administrators nationwide of the importance of EEG as a critical complement to existing ED protocols.