Pilot Study of an Internet-based Cognitive Stimulation Program in AIDS

基于互联网的艾滋病认知刺激项目试点研究

• 批准号: 7414939
• 负责人: JAMES T. BECKER
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-27 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7414939
• 关键词: AIDS Dementia Complex; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Activities of Daily Living; Affect; Anti-Retroviral Agents; Classification; Cognition Disorders; Cognitive; Computers; Consensus; Development; Diagnostic; Enrollment; Evaluation; Family; Funding; HIV; Healthcare; Highly Active Antiretroviral Therapy; Impaired cognition; Incidence; Individual; Internet; Measures; Moods; Neurocognitive; Outcome; Participant; Patient Self-Report; Patients; Peptide T; Perceived quality of life; Pharmaceutical Preparations; Pilot Projects; Prevalence; Protocols documentation; Purpose; Quality of life; Relative (related person); Ritalin; Rosa; Score; Sensitivity and Specificity; Social Work; Specific qualifier value; Standards of Weights and Measures; Symptoms; Testing; Thinking; adjudication; base; cognitive function; computerized; design; falls; improved; mild neurocognitive impairment; neurobehavioral; neuropsychological; programs; success; tool

DESCRIPTION (provided by applicant): The neurocognitive manifestations of HIV/AIDS have long been recognized as important for the management, survival, and quality of life of affected patients and their families. Following the advent of Highly active anti-retroviral therapy (HAART) the incidence of HIV-associated dementia (HAD) has fallen, but the prevalence of the milder forms of HIV-related cognitive disorders has risen. This is important because alterations in cognitive function can have significant impact on work and social activities, mood, and perceived quality of life. To date, pharmacological management of HIV-associated cognitive disorders - apart from HAART - have met with limited success (e.g., Peptide T, Ritalin). Therefore, it appears reasonable to ask whether the use of non-pharmacological tools might help alleviate or ameliorate the symptoms of the milder forms of cognitive impairment, and thus improve mood and activities of daily living. The purpose of this application is to request funds to allow us to complete a feasibility/pilot study of the merits of using an internet-based cognitive stimulation program (CSP) to improve the cognitive functions and quality of life of individuals with HIV/AIDS, and, secondarily, to detect such changes using a computerized assessment tool designed for use in a health care practitioner's office (Computer-Based Assessment of Mild Cognitive Impairment (CAMCI)). There has been little success in treating the cognitive (thinking) problems associated with HIV/AIDS using medications. The purpose of this study is to determine whether an internet-based cognitive "stimulation" program might help HIV-infected individuals think more clearly. If this is true, then it means that people with mild forms of cognitive impairment may be able to help themselves to get better.

描述(申请人提供)：长期以来，艾滋病毒/艾滋病的神经认知表现一直被认为对受影响患者及其家人的管理、生存和生活质量非常重要。随着高效抗逆转录病毒疗法(HAART)的出现，艾滋病毒相关痴呆(HAD)的发病率有所下降，但较轻微形式的艾滋病毒相关认知障碍的患病率有所上升。这一点很重要，因为认知功能的变化会对工作和社会活动、情绪和感知的生活质量产生重大影响。到目前为止，除HAART外，HIV相关认知障碍的药物治疗取得的成功有限(例如，肽T、利他林)。因此，似乎有理由问，非药物工具的使用是否有助于缓解或改善轻度认知障碍的症状，从而改善情绪和日常生活活动。本申请的目的是申请资金，以允许我们完成使用基于互联网的认知刺激计划(CSP)来改善艾滋病毒/艾滋病患者的认知功能和生活质量的优点的可行性/试点研究，其次，使用为医疗从业者办公室设计的计算机化评估工具(基于计算机的轻度认知损害评估(CAMCI))来检测这种变化。 在使用药物治疗与艾滋病毒/艾滋病相关的认知(思维)问题方面，收效甚微。这项研究的目的是确定基于互联网的认知“刺激”计划是否可以帮助艾滋病毒感染者更清楚地思考。如果这是真的，那么这意味着患有轻度认知障碍的人可能能够帮助自己变得更好。