Pilot Study of an Internet-based Cognitive Stimulation Program in AIDS

描述（由申请人提供）：HIV/AIDS的神经认知表现长期以来被认为对受影响患者及其家属的管理、生存和生活质量至关重要。随着高效抗逆转录病毒疗法（HAART）的出现，艾滋病毒相关性痴呆（HAD）的发病率有所下降，但较轻形式的艾滋病毒相关性认知障碍的患病率有所上升。这一点很重要，因为认知功能的改变会对工作和社交活动、情绪和感知的生活质量产生重大影响。迄今为止，HIV相关认知障碍的药物管理-除了HAART -已经取得了有限的成功（例如，肽T，利他林）。因此，似乎有理由询问使用非药物工具是否有助于缓解或改善轻度认知障碍的症状，从而改善情绪和日常生活活动。本申请的目的是申请资金，使我们能够完成一项可行性/试点研究，研究使用基于互联网的认知刺激计划（CSP）来改善艾滋病毒/艾滋病患者的认知功能和生活质量的优点，其次，使用设计用于健康护理从业者办公室的计算机化评估工具来检测这种变化轻度认知障碍的计算机评估（CAMCI）。 使用药物治疗与艾滋病毒/艾滋病相关的认知（思维）问题几乎没有成功。这项研究的目的是确定基于互联网的认知“刺激”计划是否可以帮助艾滋病毒感染者更清楚地思考。如果这是真的，那么这意味着患有轻度认知障碍的人可能能够帮助自己变得更好。

DESCRIPTION (provided by applicant): The neurocognitive manifestations of HIV/AIDS have long been recognized as important for the management, survival, and quality of life of affected patients and their families. Following the advent of Highly active anti-retroviral therapy (HAART) the incidence of HIV-associated dementia (HAD) has fallen, but the prevalence of the milder forms of HIV-related cognitive disorders has risen. This is important because alterations in cognitive function can have significant impact on work and social activities, mood, and perceived quality of life. To date, pharmacological management of HIV-associated cognitive disorders - apart from HAART - have met with limited success (e.g., Peptide T, Ritalin). Therefore, it appears reasonable to ask whether the use of non-pharmacological tools might help alleviate or ameliorate the symptoms of the milder forms of cognitive impairment, and thus improve mood and activities of daily living. The purpose of this application is to request funds to allow us to complete a feasibility/pilot study of the merits of using an internet-based cognitive stimulation program (CSP) to improve the cognitive functions and quality of life of individuals with HIV/AIDS, and, secondarily, to detect such changes using a computerized assessment tool designed for use in a health care practitioner's office (Computer-Based Assessment of Mild Cognitive Impairment (CAMCI)). There has been little success in treating the cognitive (thinking) problems associated with HIV/AIDS using medications. The purpose of this study is to determine whether an internet-based cognitive "stimulation" program might help HIV-infected individuals think more clearly. If this is true, then it means that people with mild forms of cognitive impairment may be able to help themselves to get better.