COMPUTER AIDED DIAGNOSIS OF PATIENTS WITH NEURODEGENERATIVE DISEASE

神经退行性疾病患者的计算机辅助诊断

• 批准号: 8364229
• 负责人: JAMES T. BECKER
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364229
• 关键词: Age; Aging; Alzheimer' s Disease; Biomedical Research; Blinded; Brain; Brain Concussion; Brain imaging; Brain region; Collection; Computer-Assisted Diagnosis; Computing Methodologies; Dementia; Elderly; Funding; Grant; High Performance Computing; Hour; Human; Individual; Magnetic Resonance Imaging; National Center for Research Resources; Neurodegenerative Disorders; Pathologic Processes; Patients; Population; Principal Investigator; Process; Relative (related person); Research; Research Infrastructure; Resolution; Resources; Sampling; Scanning; Source; Time; United States National Institutes of Health; aging brain; base; cost; public health priorities

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Over the next twenty-five years, the proportion of the population over age 65 will increase 76%; therefore understanding both the normal and pathological processes involved in the aging of the human brain is of the highest public health priority. We develop a computational method that provides estimates of the "brain age" of individuals that is based solely on a high resolution Magnetic Resonance Image (MRI) of the brain of the individual, and is blinded to his or her true chronological age. To develop quantitative neuroanatomical markers for dementia, structural MR brain images must be automatically segmented and deformably registered to provide relative volumes for many brain regions as well as other morphometric information. Historically this automatic segmentation and registration has been subject to a lot of variability, but we have developed a pipeline to perform these more reliably. The processing time for a single brain is roughly 1.5 hours on a single core of a quad-core Xeon 2.8Ghz processor. We wish to process several hundred brains. 250 are available from the Pittsburgh Concussion Study, 700 from the Alzheimer Disease Research Center, and other projects have produced large collections of structural scans to be segmented and registered. This start-up grant would allow us to process at least a large fraction of this supply of scans, provide more accurate estimates of processing time, and provide us a good statistical sample of segmentation and registration results to demonstrate the reliability of the pipeline.

这个子项目是利用这些资源的众多研究子项目之一